Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

Hardev Singh; Seo Jin Kim; Dong Hoon Kang; Hye Ri Kim; Amit Sharma; Won Young Kim; Chulhun Kang; Jong Seung Kim

doi:10.1039/c8cc05175e

Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

Hardev Singh
, Seo Jin Kim
, Dong Hoon Kang
, Hye Ri Kim
, Amit Sharma
, Won Young Kim
, Chulhun Kang
, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.

Original language	English
Pages (from-to)	12353-12356
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	87
DOIs	https://doi.org/10.1039/c8cc05175e
Publication status	Published - 2018

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
General Chemistry
Catalysis

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10.1039/c8cc05175e

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title = "Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity",

abstract = "Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.",

author = "Hardev Singh and Kim, \{Seo Jin\} and Kang, \{Dong Hoon\} and Kim, \{Hye Ri\} and Amit Sharma and Kim, \{Won Young\} and Chulhun Kang and Kim, \{Jong Seung\}",

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year = "2018",

doi = "10.1039/c8cc05175e",

language = "English",

volume = "54",

pages = "12353--12356",

journal = "Chemical Communications",

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T1 - Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

AU - Singh, Hardev

AU - Kim, Seo Jin

AU - Kang, Dong Hoon

AU - Kim, Hye Ri

AU - Sharma, Amit

AU - Kim, Won Young

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2018

Y1 - 2018

N2 - Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.

AB - Herein, we report the potential of glycyrrhetinic acid (GA) as an active targeting ligand for hepatocellular carcinoma (HCC) for the development of diagnosis/therapy using small-molecule based approaches. Our preliminary results demonstrated that GA-conjugation to diagnostic/therapeutic counterparts significantly enhanced their HCC targeting ability and excellent therapeutic efficacy.

UR - https://www.scopus.com/pages/publications/85055622506

U2 - 10.1039/c8cc05175e

DO - 10.1039/c8cc05175e

M3 - Article

C2 - 30324188

AN - SCOPUS:85055622506

SN - 1359-7345

VL - 54

SP - 12353

EP - 12356

JO - Chemical Communications

JF - Chemical Communications

IS - 87

ER -

Glycyrrhetinic acid as a hepatocyte targeting unit for an anticancer drug delivery system with enhanced cell type selectivity

Abstract

Bibliographical note

ASJC Scopus subject areas

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