Gold core@CeO2 halfshell Janus nanocomposites catalyze targeted sulfate radical for periodontitis therapy

Sijia Li, Qihang Ding, Lingling Zhang, Fangyu Shi, Chengyu Liu, Tingxuan Li, Yujia Shi, Manlin Qi, Lin Wang, Biao Dong, Shuyan Song, Jiao Sun, Jong Seung Kim, Chunyan Li

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The sulfate radical (SO4•-), known for its high reactivity and long lifespan, has emerged as a potent antimicrobial agent. Its exceptional energy allows for the disruption of vital structures and metabolic pathways in bacteria that are usually inaccessible to common radicals. Despite its promising potential, the efficient generation of this radical, particularly through methods involving enzymes and photocatalysis, remains a substantial challenge. Here, we capitalized on the peroxidase (POD)-mimicking activity and photocatalytic properties of cerium oxide (CeO2) nanozymes, integrating these properties with the enhanced concept of plasma gold nanorod (GNR) to develop a half-encapsulated core@shell GNRs@CeO2 Janus heterostructure impregnated with persulfate. Under near-infrared irradiation, the GNRs generate hot electrons, thereby boosting the CeO2's enzyme-like activity and initiating a potent reactive oxygen species (ROS) storm. This distinct nanoarchitecture facilitates functional specialization, wherein the heterostructure and efficient light absorption ensured continuous hot electron flow, not only enhancing the POD-like activity of CeO2 for the production of SO4•- effectively, but also contributing a significant photothermal effect, disrupting periodontal plaque biofilm and effectively eradicating pathogens. Furthermore, the local temperature elevation synergistically enhances the POD-like activity of CeO2. Transcriptomics analysis, as well as animal experiments of the periodontitis model, have revealed that pathogens undergo genetic information destruction, metabolic disorders, and pathogenicity changes in the powerful ROS system, and profound therapeutic outcomes in vivo, including anti-inflammation and bone preservation. This study demonstrated that energy transfer to augment nanozyme activity, specifically targeting ROS generation, constitutes a significant advancement in antibacterial treatment.

Original languageEnglish
Pages (from-to)600-613
Number of pages14
JournalJournal of Controlled Release
Volume370
DOIs
Publication statusPublished - 2024 Jun

Bibliographical note

Publisher Copyright:
© 2024

Keywords

  • Antibacterial
  • Nanozyme
  • Periodontal disease
  • Photocatalytic antimicrobial therapy
  • Sulfate radicals

ASJC Scopus subject areas

  • Pharmaceutical Science

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