Gold nanoparticle embedded silicon nanowire biosensor for applications of label-free DNA detection

Seong Wan Ryu; Chang Hoon Kim; Jin Woo Han; Chung Jin Kim; Cheulhee Jung; Hyun Gyu Park; Yang Kyu Choi

doi:10.1016/j.bios.2010.02.010

Gold nanoparticle embedded silicon nanowire biosensor for applications of label-free DNA detection

Seong Wan Ryu, Chang Hoon Kim, Jin Woo Han, Chung Jin Kim, Cheulhee Jung, Hyun Gyu Park, Yang Kyu Choi

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Gold nanoparticle (GN) embedded silicon nanowire (SiNW) configuration was proposed as a new biosensor for label-free DNA detection to enhance the sensitivity. The electric current flow between two terminals, a source and a drain electrode, were measured to sense the immobilization of probe oligonucleotides and their hybridization with target oligonucleotides. The complementary target oligonucleotide, breast cancer DNA with 1. pM, was sensed. In addition, its sensing mechanism and limit of detection (LOD) enhancement was investigated through simulation. The results support that the LOD can be improved by reducing the SiNW doping concentration. This emerging architecture combined nanostructure of spherical GN and SiNW has high potential as a label-free biosensor due to its facile fabrication process, high thermal stability, immobilization efficiency with a thiol-group in a self-assembled monolayer (SAM), and improved sensitivity.

Original language	English
Pages (from-to)	2182-2185
Number of pages	4
Journal	Biosensors and Bioelectronics
Volume	25
Issue number	9
DOIs	https://doi.org/10.1016/j.bios.2010.02.010
Publication status	Published - 2010 May
Externally published	Yes

Keywords

DNA
Gold nanoparticle
Hybridization
Oligonucleotide immobilization
Silicon nanowire

ASJC Scopus subject areas

Biotechnology
Biophysics
Biomedical Engineering
Electrochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bios.2010.02.010

Cite this

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title = "Gold nanoparticle embedded silicon nanowire biosensor for applications of label-free DNA detection",

abstract = "Gold nanoparticle (GN) embedded silicon nanowire (SiNW) configuration was proposed as a new biosensor for label-free DNA detection to enhance the sensitivity. The electric current flow between two terminals, a source and a drain electrode, were measured to sense the immobilization of probe oligonucleotides and their hybridization with target oligonucleotides. The complementary target oligonucleotide, breast cancer DNA with 1. pM, was sensed. In addition, its sensing mechanism and limit of detection (LOD) enhancement was investigated through simulation. The results support that the LOD can be improved by reducing the SiNW doping concentration. This emerging architecture combined nanostructure of spherical GN and SiNW has high potential as a label-free biosensor due to its facile fabrication process, high thermal stability, immobilization efficiency with a thiol-group in a self-assembled monolayer (SAM), and improved sensitivity.",

keywords = "DNA, Gold nanoparticle, Hybridization, Oligonucleotide immobilization, Silicon nanowire",

author = "Ryu, {Seong Wan} and Kim, {Chang Hoon} and Han, {Jin Woo} and Kim, {Chung Jin} and Cheulhee Jung and Park, {Hyun Gyu} and Choi, {Yang Kyu}",

note = "Funding Information: This work was supported by the NRL Program of the Korea Science and Engineering Foundation (KOSEF) grant funded by the South Korean Government (MEST) ( ROA-2007-000-20028-0 and ROA-2007-000-20127-0 ) and the National Research and Development Program ( NRDP, 2005-01274 ) for the development of biomedical function monitoring biosensors, sponsored by the Korea Ministry of Science and Technology (MOST).",

year = "2010",

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doi = "10.1016/j.bios.2010.02.010",

language = "English",

volume = "25",

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journal = "Biosensors and Bioelectronics",

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TY - JOUR

T1 - Gold nanoparticle embedded silicon nanowire biosensor for applications of label-free DNA detection

AU - Ryu, Seong Wan

AU - Kim, Chang Hoon

AU - Han, Jin Woo

AU - Kim, Chung Jin

AU - Jung, Cheulhee

AU - Park, Hyun Gyu

AU - Choi, Yang Kyu

N1 - Funding Information: This work was supported by the NRL Program of the Korea Science and Engineering Foundation (KOSEF) grant funded by the South Korean Government (MEST) ( ROA-2007-000-20028-0 and ROA-2007-000-20127-0 ) and the National Research and Development Program ( NRDP, 2005-01274 ) for the development of biomedical function monitoring biosensors, sponsored by the Korea Ministry of Science and Technology (MOST).

PY - 2010/5

Y1 - 2010/5

N2 - Gold nanoparticle (GN) embedded silicon nanowire (SiNW) configuration was proposed as a new biosensor for label-free DNA detection to enhance the sensitivity. The electric current flow between two terminals, a source and a drain electrode, were measured to sense the immobilization of probe oligonucleotides and their hybridization with target oligonucleotides. The complementary target oligonucleotide, breast cancer DNA with 1. pM, was sensed. In addition, its sensing mechanism and limit of detection (LOD) enhancement was investigated through simulation. The results support that the LOD can be improved by reducing the SiNW doping concentration. This emerging architecture combined nanostructure of spherical GN and SiNW has high potential as a label-free biosensor due to its facile fabrication process, high thermal stability, immobilization efficiency with a thiol-group in a self-assembled monolayer (SAM), and improved sensitivity.

AB - Gold nanoparticle (GN) embedded silicon nanowire (SiNW) configuration was proposed as a new biosensor for label-free DNA detection to enhance the sensitivity. The electric current flow between two terminals, a source and a drain electrode, were measured to sense the immobilization of probe oligonucleotides and their hybridization with target oligonucleotides. The complementary target oligonucleotide, breast cancer DNA with 1. pM, was sensed. In addition, its sensing mechanism and limit of detection (LOD) enhancement was investigated through simulation. The results support that the LOD can be improved by reducing the SiNW doping concentration. This emerging architecture combined nanostructure of spherical GN and SiNW has high potential as a label-free biosensor due to its facile fabrication process, high thermal stability, immobilization efficiency with a thiol-group in a self-assembled monolayer (SAM), and improved sensitivity.

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KW - Hybridization

KW - Oligonucleotide immobilization

KW - Silicon nanowire

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Gold nanoparticle embedded silicon nanowire biosensor for applications of label-free DNA detection

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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