Gold nanorod-mediated photothermal modulation for localized ablation of cancer cells

Yoochan Hong; Eugene Lee; Jihye Choi; Seung Jae Oh; Seungjoo Haam; Yong Min Huh; Dae Sung Yoon; Jin Suck Suh; Jaemoon Yang

doi:10.1155/2012/825060

Gold nanorod-mediated photothermal modulation for localized ablation of cancer cells

Yoochan Hong, Eugene Lee, Jihye Choi, Seung Jae Oh, Seungjoo Haam, Yong Min Huh, Dae Sung Yoon, Jin Suck Suh, Jaemoon Yang

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We estimated the photothermal transduction efficiency of gold nanorod (GNR) solutions for different GNR concentrations and irradiation laser power. In particular, we verified that the degree of cell death area could be modulated by GNR concentration and irradiation laser power. The efficacy of GNR-produced photothermal ablation of cancer cells was evaluated by irradiating GNRs in the presence of MDA-MB-231 breast cancer cells with a near-infrared (NIR) laser at different laser power densities and irradiation times. GNR-induced photothermal ablation was applied successfully to cancer cells at various NIR laser power densities and irradiation times and was characterized with live-dead cell staining. Through these techniques, we established the system for not only verification of induced photothermal effect using NIR laser and thermocouple, but also identification of uptake efficiency for GNRs and cell viability using dark field and fluorescence imaging, respectively.

Original language	English
Article number	825060
Journal	Journal of Nanomaterials
Volume	2012
DOIs	https://doi.org/10.1155/2012/825060
Publication status	Published - 2012
Externally published	Yes

ASJC Scopus subject areas

Materials Science(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1155/2012/825060

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title = "Gold nanorod-mediated photothermal modulation for localized ablation of cancer cells",

abstract = "We estimated the photothermal transduction efficiency of gold nanorod (GNR) solutions for different GNR concentrations and irradiation laser power. In particular, we verified that the degree of cell death area could be modulated by GNR concentration and irradiation laser power. The efficacy of GNR-produced photothermal ablation of cancer cells was evaluated by irradiating GNRs in the presence of MDA-MB-231 breast cancer cells with a near-infrared (NIR) laser at different laser power densities and irradiation times. GNR-induced photothermal ablation was applied successfully to cancer cells at various NIR laser power densities and irradiation times and was characterized with live-dead cell staining. Through these techniques, we established the system for not only verification of induced photothermal effect using NIR laser and thermocouple, but also identification of uptake efficiency for GNRs and cell viability using dark field and fluorescence imaging, respectively.",

author = "Yoochan Hong and Eugene Lee and Jihye Choi and Oh, {Seung Jae} and Seungjoo Haam and Huh, {Yong Min} and Yoon, {Dae Sung} and Suh, {Jin Suck} and Jaemoon Yang",

year = "2012",

doi = "10.1155/2012/825060",

language = "English",

volume = "2012",

journal = "Journal of Nanomaterials",

issn = "1687-4110",

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T1 - Gold nanorod-mediated photothermal modulation for localized ablation of cancer cells

AU - Hong, Yoochan

AU - Lee, Eugene

AU - Choi, Jihye

AU - Oh, Seung Jae

AU - Haam, Seungjoo

AU - Huh, Yong Min

AU - Yoon, Dae Sung

AU - Suh, Jin Suck

AU - Yang, Jaemoon

PY - 2012

Y1 - 2012

N2 - We estimated the photothermal transduction efficiency of gold nanorod (GNR) solutions for different GNR concentrations and irradiation laser power. In particular, we verified that the degree of cell death area could be modulated by GNR concentration and irradiation laser power. The efficacy of GNR-produced photothermal ablation of cancer cells was evaluated by irradiating GNRs in the presence of MDA-MB-231 breast cancer cells with a near-infrared (NIR) laser at different laser power densities and irradiation times. GNR-induced photothermal ablation was applied successfully to cancer cells at various NIR laser power densities and irradiation times and was characterized with live-dead cell staining. Through these techniques, we established the system for not only verification of induced photothermal effect using NIR laser and thermocouple, but also identification of uptake efficiency for GNRs and cell viability using dark field and fluorescence imaging, respectively.

AB - We estimated the photothermal transduction efficiency of gold nanorod (GNR) solutions for different GNR concentrations and irradiation laser power. In particular, we verified that the degree of cell death area could be modulated by GNR concentration and irradiation laser power. The efficacy of GNR-produced photothermal ablation of cancer cells was evaluated by irradiating GNRs in the presence of MDA-MB-231 breast cancer cells with a near-infrared (NIR) laser at different laser power densities and irradiation times. GNR-induced photothermal ablation was applied successfully to cancer cells at various NIR laser power densities and irradiation times and was characterized with live-dead cell staining. Through these techniques, we established the system for not only verification of induced photothermal effect using NIR laser and thermocouple, but also identification of uptake efficiency for GNRs and cell viability using dark field and fluorescence imaging, respectively.

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DO - 10.1155/2012/825060

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JO - Journal of Nanomaterials

JF - Journal of Nanomaterials

M1 - 825060

ER -

Gold nanorod-mediated photothermal modulation for localized ablation of cancer cells

Abstract

ASJC Scopus subject areas

UN SDGs

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