Gold nanorods-encapsulated thermosensitive drug carriers for NIR light-responsive anticancer therapy

Yoon Ho Roh; Ji Yeon Eom; Dae Gun Choi; Ju Yeon Moon; Min Suk Shim; Ki Wan Bong

doi:10.1016/j.jiec.2021.03.052

Gold nanorods-encapsulated thermosensitive drug carriers for NIR light-responsive anticancer therapy

Yoon Ho Roh, Ji Yeon Eom, Dae Gun Choi, Ju Yeon Moon, Min Suk Shim, Ki Wan Bong

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Thermoresponsive polymers incorporated with photo-absorbing agents have been widely utilized for controlled drug delivery using light as an external stimulus. However, previously developed thermoresponsive drug carriers have disadvantages such as low biocompatibility and implantation failure. In the present study, gold nanorods (GNRs)-encapsulated poly(N-vinyl caprolactam) (PVCL) (GNR-PVCL) microparticles were synthesized by the stop-flow lithography (SFL) method. The SFL method enabled the fabrication of near-infrared (NIR) light-responsive GNR-PVCL microparticles of uniform size, which can allow localized injection. Doxorubicin (DOX) was encapsulated into GNR-PVCL microparticles to achieve NIR light-responsive anticancer therapy. DOX-loaded GNR-PVCL (DOX-GNR-PVCL) microparticles exhibited NIR light-triggered drug release due to the photothermal effect of GNRs, which increases the local temperature above the volume phase transition temperature of GNR-PVCL microparticles. In addition, DOX-GNR-PVCL exhibited controlled DOX release in response to the periodic irradiation of NIR light. Moreover, we demonstrated the efficient intracellular release of DOX upon NIR light exposure, and thus, NIR light-responsive anticancer activity. This study demonstrates that DOX-GNR-PVCL microparticles have significant potential as implantable drug carriers enabling NIR light-triggered drug release.

Original language	English
Pages (from-to)	211-216
Number of pages	6
Journal	Journal of Industrial and Engineering Chemistry
Volume	98
DOIs	https://doi.org/10.1016/j.jiec.2021.03.052
Publication status	Published - 2021 Jun 25

Keywords

Cancer therapy
Gold nanorod
NIR light
Photothermal effect
Poly(N-vinyl caprolactam)
Stop-flow lithography

ASJC Scopus subject areas

Chemical Engineering(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jiec.2021.03.052

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@article{47e527ad4950480c85f265dfa6881cfa,

title = "Gold nanorods-encapsulated thermosensitive drug carriers for NIR light-responsive anticancer therapy",

abstract = "Thermoresponsive polymers incorporated with photo-absorbing agents have been widely utilized for controlled drug delivery using light as an external stimulus. However, previously developed thermoresponsive drug carriers have disadvantages such as low biocompatibility and implantation failure. In the present study, gold nanorods (GNRs)-encapsulated poly(N-vinyl caprolactam) (PVCL) (GNR-PVCL) microparticles were synthesized by the stop-flow lithography (SFL) method. The SFL method enabled the fabrication of near-infrared (NIR) light-responsive GNR-PVCL microparticles of uniform size, which can allow localized injection. Doxorubicin (DOX) was encapsulated into GNR-PVCL microparticles to achieve NIR light-responsive anticancer therapy. DOX-loaded GNR-PVCL (DOX-GNR-PVCL) microparticles exhibited NIR light-triggered drug release due to the photothermal effect of GNRs, which increases the local temperature above the volume phase transition temperature of GNR-PVCL microparticles. In addition, DOX-GNR-PVCL exhibited controlled DOX release in response to the periodic irradiation of NIR light. Moreover, we demonstrated the efficient intracellular release of DOX upon NIR light exposure, and thus, NIR light-responsive anticancer activity. This study demonstrates that DOX-GNR-PVCL microparticles have significant potential as implantable drug carriers enabling NIR light-triggered drug release.",

keywords = "Cancer therapy, Gold nanorod, NIR light, Photothermal effect, Poly(N-vinyl caprolactam), Stop-flow lithography",

author = "Roh, {Yoon Ho} and Eom, {Ji Yeon} and Choi, {Dae Gun} and Moon, {Ju Yeon} and Shim, {Min Suk} and Bong, {Ki Wan}",

note = "Funding Information: This work has been supported by the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT, Korea) ( NRF-2016R1A5A1010148 ), the Basic Science Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( NRF-2018R1D1A1B07046577 ). This work has been supported by the Next-Generation Biogreen 21 Program funded by Rural Development Administration of Republic of Korea (No. PJ016004 ). This work has also been supported by the National Research Foundation of Korea (NRF) grants funded by the MSIT ( NRF-2019R1F1A1057762 ). Publisher Copyright: {\textcopyright} 2021 The Korean Society of Industrial and Engineering Chemistry",

year = "2021",

month = jun,

day = "25",

doi = "10.1016/j.jiec.2021.03.052",

language = "English",

volume = "98",

pages = "211--216",

journal = "Journal of Industrial and Engineering Chemistry",

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publisher = "Korean Society of Industrial Engineering Chemistry",

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TY - JOUR

T1 - Gold nanorods-encapsulated thermosensitive drug carriers for NIR light-responsive anticancer therapy

AU - Roh, Yoon Ho

AU - Eom, Ji Yeon

AU - Choi, Dae Gun

AU - Moon, Ju Yeon

AU - Shim, Min Suk

AU - Bong, Ki Wan

N1 - Funding Information: This work has been supported by the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT, Korea) ( NRF-2016R1A5A1010148 ), the Basic Science Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( NRF-2018R1D1A1B07046577 ). This work has been supported by the Next-Generation Biogreen 21 Program funded by Rural Development Administration of Republic of Korea (No. PJ016004 ). This work has also been supported by the National Research Foundation of Korea (NRF) grants funded by the MSIT ( NRF-2019R1F1A1057762 ). Publisher Copyright: © 2021 The Korean Society of Industrial and Engineering Chemistry

PY - 2021/6/25

Y1 - 2021/6/25

N2 - Thermoresponsive polymers incorporated with photo-absorbing agents have been widely utilized for controlled drug delivery using light as an external stimulus. However, previously developed thermoresponsive drug carriers have disadvantages such as low biocompatibility and implantation failure. In the present study, gold nanorods (GNRs)-encapsulated poly(N-vinyl caprolactam) (PVCL) (GNR-PVCL) microparticles were synthesized by the stop-flow lithography (SFL) method. The SFL method enabled the fabrication of near-infrared (NIR) light-responsive GNR-PVCL microparticles of uniform size, which can allow localized injection. Doxorubicin (DOX) was encapsulated into GNR-PVCL microparticles to achieve NIR light-responsive anticancer therapy. DOX-loaded GNR-PVCL (DOX-GNR-PVCL) microparticles exhibited NIR light-triggered drug release due to the photothermal effect of GNRs, which increases the local temperature above the volume phase transition temperature of GNR-PVCL microparticles. In addition, DOX-GNR-PVCL exhibited controlled DOX release in response to the periodic irradiation of NIR light. Moreover, we demonstrated the efficient intracellular release of DOX upon NIR light exposure, and thus, NIR light-responsive anticancer activity. This study demonstrates that DOX-GNR-PVCL microparticles have significant potential as implantable drug carriers enabling NIR light-triggered drug release.

AB - Thermoresponsive polymers incorporated with photo-absorbing agents have been widely utilized for controlled drug delivery using light as an external stimulus. However, previously developed thermoresponsive drug carriers have disadvantages such as low biocompatibility and implantation failure. In the present study, gold nanorods (GNRs)-encapsulated poly(N-vinyl caprolactam) (PVCL) (GNR-PVCL) microparticles were synthesized by the stop-flow lithography (SFL) method. The SFL method enabled the fabrication of near-infrared (NIR) light-responsive GNR-PVCL microparticles of uniform size, which can allow localized injection. Doxorubicin (DOX) was encapsulated into GNR-PVCL microparticles to achieve NIR light-responsive anticancer therapy. DOX-loaded GNR-PVCL (DOX-GNR-PVCL) microparticles exhibited NIR light-triggered drug release due to the photothermal effect of GNRs, which increases the local temperature above the volume phase transition temperature of GNR-PVCL microparticles. In addition, DOX-GNR-PVCL exhibited controlled DOX release in response to the periodic irradiation of NIR light. Moreover, we demonstrated the efficient intracellular release of DOX upon NIR light exposure, and thus, NIR light-responsive anticancer activity. This study demonstrates that DOX-GNR-PVCL microparticles have significant potential as implantable drug carriers enabling NIR light-triggered drug release.

KW - Cancer therapy

KW - Gold nanorod

KW - NIR light

KW - Photothermal effect

KW - Poly(N-vinyl caprolactam)

KW - Stop-flow lithography

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U2 - 10.1016/j.jiec.2021.03.052

DO - 10.1016/j.jiec.2021.03.052

M3 - Article

AN - SCOPUS:85104460443

SN - 1226-086X

VL - 98

SP - 211

EP - 216

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

Gold nanorods-encapsulated thermosensitive drug carriers for NIR light-responsive anticancer therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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