Gold nanorods-encapsulated thermosensitive drug carriers for NIR light-responsive anticancer therapy

Yoon Ho Roh, Ji Yeon Eom, Dae Gun Choi, Ju Yeon Moon, Min Suk Shim, Ki Wan Bong

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Thermoresponsive polymers incorporated with photo-absorbing agents have been widely utilized for controlled drug delivery using light as an external stimulus. However, previously developed thermoresponsive drug carriers have disadvantages such as low biocompatibility and implantation failure. In the present study, gold nanorods (GNRs)-encapsulated poly(N-vinyl caprolactam) (PVCL) (GNR-PVCL) microparticles were synthesized by the stop-flow lithography (SFL) method. The SFL method enabled the fabrication of near-infrared (NIR) light-responsive GNR-PVCL microparticles of uniform size, which can allow localized injection. Doxorubicin (DOX) was encapsulated into GNR-PVCL microparticles to achieve NIR light-responsive anticancer therapy. DOX-loaded GNR-PVCL (DOX-GNR-PVCL) microparticles exhibited NIR light-triggered drug release due to the photothermal effect of GNRs, which increases the local temperature above the volume phase transition temperature of GNR-PVCL microparticles. In addition, DOX-GNR-PVCL exhibited controlled DOX release in response to the periodic irradiation of NIR light. Moreover, we demonstrated the efficient intracellular release of DOX upon NIR light exposure, and thus, NIR light-responsive anticancer activity. This study demonstrates that DOX-GNR-PVCL microparticles have significant potential as implantable drug carriers enabling NIR light-triggered drug release.

Original languageEnglish
Pages (from-to)211-216
Number of pages6
JournalJournal of Industrial and Engineering Chemistry
Volume98
DOIs
Publication statusPublished - 2021 Jun 25

Bibliographical note

Funding Information:
This work has been supported by the Engineering Research Center of Excellence Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT, Korea) ( NRF-2016R1A5A1010148 ), the Basic Science Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education ( NRF-2018R1D1A1B07046577 ). This work has been supported by the Next-Generation Biogreen 21 Program funded by Rural Development Administration of Republic of Korea (No. PJ016004 ). This work has also been supported by the National Research Foundation of Korea (NRF) grants funded by the MSIT ( NRF-2019R1F1A1057762 ).

Publisher Copyright:
© 2021 The Korean Society of Industrial and Engineering Chemistry

Keywords

  • Cancer therapy
  • Gold nanorod
  • NIR light
  • Photothermal effect
  • Poly(N-vinyl caprolactam)
  • Stop-flow lithography

ASJC Scopus subject areas

  • General Chemical Engineering

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