Gold Nanotetrapods with Unique Topological Structure and Ultranarrow Plasmonic Band as Multifunctional Therapeutic Agents

Yi Xin Chang; Ning Ning Zhang; Yu Chen Xing; Qingfeng Zhang; Aram Oh; Hui Min Gao; Yun Zhu; Hionsuck Baik; Byeongyoon Kim; Yang Yang; Wei Shun Chang; Tianmeng Sun; Junhu Zhang; Zhong Yuan Lu; Kwangyeol Lee; Stephan Link; Kun Liu

doi:10.1021/acs.jpclett.9b01589

Gold Nanotetrapods with Unique Topological Structure and Ultranarrow Plasmonic Band as Multifunctional Therapeutic Agents

Yi Xin Chang, Ning Ning Zhang, Yu Chen Xing, Qingfeng Zhang, Aram Oh, Hui Min Gao, Yun Zhu, Hionsuck Baik, Byeongyoon Kim, Yang Yang, Wei Shun Chang, Tianmeng Sun, Junhu Zhang, Zhong Yuan Lu, Kwangyeol Lee, Stephan Link, Kun Liu

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Owing to their excellent surface plasmonic properties, Au nanobranches have drawn increasing attention in various bioapplications, such as contrast agents for photoacoustic imaging, nanomedicines for photothermal therapy, and carriers for drug delivery. The monodispersity and plasmonic bandwidth of Au nanobranches are of great importance for the efficacy of those bioapplications. However, it is still a challenge to accurately synthesize size- and shape-controlled Au nanobranches. Here we report a facile seed-mediated growth method to synthesize monodisperse Au nanotetrapods (NTPs) with tunable and ultranarrow plasmonic bands. The NTPs have a novel D_2d symmetry with four arms elongated in four 110»directions. The growth mechanism of NTPs relies on the delicate kinetic control of deposition and diffusion rates of adatoms. Upon laser irradiation, the PEGylated NTPs possess remarkable photothermal conversion efficiencies and photoacoustic imaging properties. The NTPs can be applied as a multifunctional theranostic agent for both photoacoustic imaging and image-guided photothermal therapy.

Original language	English
Pages (from-to)	4505-4510
Number of pages	6
Journal	Journal of Physical Chemistry Letters
Volume	10
Issue number	16
DOIs	https://doi.org/10.1021/acs.jpclett.9b01589
Publication status	Published - 2019 Aug 15

Bibliographical note

Funding Information:
K.L. thanks the National Natural Science Foundation of China (21674042 and 21474040) for financial support. K.L. and Z.-Y.L. gratefully acknowledge financial support from the National Natural Science Foundation of China (21534004). K.L. and T.S. thank the Interdisciplinary Innovation Project of the First Hospital of Jilin University (JDYYJCHX001). This work is also supported by Program for JLU Science and Technology Innovative Research Team “JLUSTIRT2017TD-06” and the opening funds of State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science. S.L. acknowledges support from the Robert A. Welch Foundation (C-1664) and the National Science Foundation (CHE1507745). Q.Z. acknowledges support from the Smalley-Curl Institute at Rice University through a J Evans Attwell-Welch Postdoctoral Fellowship.

Publisher Copyright:
© 2019 American Chemical Society.

ASJC Scopus subject areas

Materials Science(all)
Physical and Theoretical Chemistry

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10.1021/acs.jpclett.9b01589

Cite this

Chang, Y. X., Zhang, N. N., Xing, Y. C., Zhang, Q., Oh, A., Gao, H. M., Zhu, Y., Baik, H., Kim, B., Yang, Y., Chang, W. S., Sun, T., Zhang, J., Lu, Z. Y., Lee, K., Link, S., & Liu, K. (2019). Gold Nanotetrapods with Unique Topological Structure and Ultranarrow Plasmonic Band as Multifunctional Therapeutic Agents. Journal of Physical Chemistry Letters, 10(16), 4505-4510. https://doi.org/10.1021/acs.jpclett.9b01589

Chang, YX, Zhang, NN, Xing, YC, Zhang, Q, Oh, A, Gao, HM, Zhu, Y, Baik, H, Kim, B, Yang, Y, Chang, WS, Sun, T, Zhang, J, Lu, ZY, Lee, K, Link, S & Liu, K 2019, 'Gold Nanotetrapods with Unique Topological Structure and Ultranarrow Plasmonic Band as Multifunctional Therapeutic Agents', Journal of Physical Chemistry Letters, vol. 10, no. 16, pp. 4505-4510. https://doi.org/10.1021/acs.jpclett.9b01589

@article{2430b4e4940d49cc8814e9f0e8523b42,

title = "Gold Nanotetrapods with Unique Topological Structure and Ultranarrow Plasmonic Band as Multifunctional Therapeutic Agents",

abstract = "Owing to their excellent surface plasmonic properties, Au nanobranches have drawn increasing attention in various bioapplications, such as contrast agents for photoacoustic imaging, nanomedicines for photothermal therapy, and carriers for drug delivery. The monodispersity and plasmonic bandwidth of Au nanobranches are of great importance for the efficacy of those bioapplications. However, it is still a challenge to accurately synthesize size- and shape-controlled Au nanobranches. Here we report a facile seed-mediated growth method to synthesize monodisperse Au nanotetrapods (NTPs) with tunable and ultranarrow plasmonic bands. The NTPs have a novel D2d symmetry with four arms elongated in four 110»directions. The growth mechanism of NTPs relies on the delicate kinetic control of deposition and diffusion rates of adatoms. Upon laser irradiation, the PEGylated NTPs possess remarkable photothermal conversion efficiencies and photoacoustic imaging properties. The NTPs can be applied as a multifunctional theranostic agent for both photoacoustic imaging and image-guided photothermal therapy.",

author = "Chang, {Yi Xin} and Zhang, {Ning Ning} and Xing, {Yu Chen} and Qingfeng Zhang and Aram Oh and Gao, {Hui Min} and Yun Zhu and Hionsuck Baik and Byeongyoon Kim and Yang Yang and Chang, {Wei Shun} and Tianmeng Sun and Junhu Zhang and Lu, {Zhong Yuan} and Kwangyeol Lee and Stephan Link and Kun Liu",

note = "Funding Information: K.L. thanks the National Natural Science Foundation of China (21674042 and 21474040) for financial support. K.L. and Z.-Y.L. gratefully acknowledge financial support from the National Natural Science Foundation of China (21534004). K.L. and T.S. thank the Interdisciplinary Innovation Project of the First Hospital of Jilin University (JDYYJCHX001). This work is also supported by Program for JLU Science and Technology Innovative Research Team “JLUSTIRT2017TD-06” and the opening funds of State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science. S.L. acknowledges support from the Robert A. Welch Foundation (C-1664) and the National Science Foundation (CHE1507745). Q.Z. acknowledges support from the Smalley-Curl Institute at Rice University through a J Evans Attwell-Welch Postdoctoral Fellowship. Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",

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doi = "10.1021/acs.jpclett.9b01589",

language = "English",

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AU - Chang, Yi Xin

AU - Zhang, Ning Ning

AU - Xing, Yu Chen

AU - Zhang, Qingfeng

AU - Oh, Aram

AU - Gao, Hui Min

AU - Zhu, Yun

AU - Baik, Hionsuck

AU - Kim, Byeongyoon

AU - Yang, Yang

AU - Chang, Wei Shun

AU - Sun, Tianmeng

AU - Zhang, Junhu

AU - Lu, Zhong Yuan

AU - Lee, Kwangyeol

AU - Link, Stephan

AU - Liu, Kun

N1 - Funding Information: K.L. thanks the National Natural Science Foundation of China (21674042 and 21474040) for financial support. K.L. and Z.-Y.L. gratefully acknowledge financial support from the National Natural Science Foundation of China (21534004). K.L. and T.S. thank the Interdisciplinary Innovation Project of the First Hospital of Jilin University (JDYYJCHX001). This work is also supported by Program for JLU Science and Technology Innovative Research Team “JLUSTIRT2017TD-06” and the opening funds of State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science. S.L. acknowledges support from the Robert A. Welch Foundation (C-1664) and the National Science Foundation (CHE1507745). Q.Z. acknowledges support from the Smalley-Curl Institute at Rice University through a J Evans Attwell-Welch Postdoctoral Fellowship. Publisher Copyright: © 2019 American Chemical Society.

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Owing to their excellent surface plasmonic properties, Au nanobranches have drawn increasing attention in various bioapplications, such as contrast agents for photoacoustic imaging, nanomedicines for photothermal therapy, and carriers for drug delivery. The monodispersity and plasmonic bandwidth of Au nanobranches are of great importance for the efficacy of those bioapplications. However, it is still a challenge to accurately synthesize size- and shape-controlled Au nanobranches. Here we report a facile seed-mediated growth method to synthesize monodisperse Au nanotetrapods (NTPs) with tunable and ultranarrow plasmonic bands. The NTPs have a novel D2d symmetry with four arms elongated in four 110»directions. The growth mechanism of NTPs relies on the delicate kinetic control of deposition and diffusion rates of adatoms. Upon laser irradiation, the PEGylated NTPs possess remarkable photothermal conversion efficiencies and photoacoustic imaging properties. The NTPs can be applied as a multifunctional theranostic agent for both photoacoustic imaging and image-guided photothermal therapy.

AB - Owing to their excellent surface plasmonic properties, Au nanobranches have drawn increasing attention in various bioapplications, such as contrast agents for photoacoustic imaging, nanomedicines for photothermal therapy, and carriers for drug delivery. The monodispersity and plasmonic bandwidth of Au nanobranches are of great importance for the efficacy of those bioapplications. However, it is still a challenge to accurately synthesize size- and shape-controlled Au nanobranches. Here we report a facile seed-mediated growth method to synthesize monodisperse Au nanotetrapods (NTPs) with tunable and ultranarrow plasmonic bands. The NTPs have a novel D2d symmetry with four arms elongated in four 110»directions. The growth mechanism of NTPs relies on the delicate kinetic control of deposition and diffusion rates of adatoms. Upon laser irradiation, the PEGylated NTPs possess remarkable photothermal conversion efficiencies and photoacoustic imaging properties. The NTPs can be applied as a multifunctional theranostic agent for both photoacoustic imaging and image-guided photothermal therapy.

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IS - 16

ER -

Gold Nanotetrapods with Unique Topological Structure and Ultranarrow Plasmonic Band as Multifunctional Therapeutic Agents

Abstract

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ASJC Scopus subject areas

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