Graphene assisted terahertz metamaterials for sensitive bio-sensing

Sang Hun Lee; Jong Ho Choe; Chulki Kim; Sukang Bae; Jin Soo Kim; Q. Han Park; Minah Seo

doi:10.1016/j.snb.2020.127841

Graphene assisted terahertz metamaterials for sensitive bio-sensing

Sang Hun Lee, Jong Ho Choe, Chulki Kim, Sukang Bae, Jin Soo Kim, Q. Han Park, Minah Seo

Department of Physics

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

We report that single-stranded deoxyribonucleic acids (ssDNAs) at very low concentrations can be detected using graphene-combined nano-slot-based terahertz (THz) resonance. A combination of the resonant structure and tuned electro-optical properties of graphene can provide unprecedentedly sensitive biomolecule sensing even using very low energy THz photons, overcoming the huge scale difference of 10,000:1 between the wavelength and the size of the ssDNAs. Ultrahigh sensitivity is obtained by the significant increase in the absorption cross-section of the graphene sheet with the targeted biomolecules, induced by strong THz field enhancement at the resonance frequency inside the slots. Clearly distinguishable THz optical signals were observed between different species of ssDNAs even at the nano-mole level and analyzed quantitatively in terms of the electro-optical properties of the suspended graphene layer modified by the attached ssDNAs without any molecular-specific labeling for the THz regime. Quantitative analysis of ssDNA molecule adsorption was carried based on the change in conductivity using a theoretical THz transmission model.

Original language	English
Article number	127841
Journal	Sensors and Actuators, B: Chemical
Volume	310
DOIs	https://doi.org/10.1016/j.snb.2020.127841
Publication status	Published - 2020 May 1

Bibliographical note

Funding Information:
This research was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (NRF-2016R1A2B2010858 and NRF-2017R1A6A3A11034292 and the Global Frontier Program CAMM-2019M3A6B3030638 and CAMM-2014M3A6B3063710), and KIST intramural grants (2E29490 and 2V06780).

Funding Information:
This research was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (NRF- 2016R1A2B2010858 and NRF - 2017R1A6A3A11034292 and the Global Frontier Program CAMM - 2019M3A6B3030638 and CAMM - 2014M3A6B3063710 ), and KIST intramural grants ( 2E29490 and 2V06780 ).

Publisher Copyright:
© 2020 The Author(s)

Keywords

Biosensor
Graphene
Metamaterial
Terahertz

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1016/j.snb.2020.127841

Cite this

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title = "Graphene assisted terahertz metamaterials for sensitive bio-sensing",

abstract = "We report that single-stranded deoxyribonucleic acids (ssDNAs) at very low concentrations can be detected using graphene-combined nano-slot-based terahertz (THz) resonance. A combination of the resonant structure and tuned electro-optical properties of graphene can provide unprecedentedly sensitive biomolecule sensing even using very low energy THz photons, overcoming the huge scale difference of 10,000:1 between the wavelength and the size of the ssDNAs. Ultrahigh sensitivity is obtained by the significant increase in the absorption cross-section of the graphene sheet with the targeted biomolecules, induced by strong THz field enhancement at the resonance frequency inside the slots. Clearly distinguishable THz optical signals were observed between different species of ssDNAs even at the nano-mole level and analyzed quantitatively in terms of the electro-optical properties of the suspended graphene layer modified by the attached ssDNAs without any molecular-specific labeling for the THz regime. Quantitative analysis of ssDNA molecule adsorption was carried based on the change in conductivity using a theoretical THz transmission model.",

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note = "Funding Information: This research was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (NRF-2016R1A2B2010858 and NRF-2017R1A6A3A11034292 and the Global Frontier Program CAMM-2019M3A6B3030638 and CAMM-2014M3A6B3063710), and KIST intramural grants (2E29490 and 2V06780). Funding Information: This research was supported by a National Research Foundation of Korea (NRF) grant funded by the Korean government (NRF- 2016R1A2B2010858 and NRF - 2017R1A6A3A11034292 and the Global Frontier Program CAMM - 2019M3A6B3030638 and CAMM - 2014M3A6B3063710 ), and KIST intramural grants ( 2E29490 and 2V06780 ). Publisher Copyright: {\textcopyright} 2020 The Author(s)",

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AU - Park, Q. Han

AU - Seo, Minah

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N2 - We report that single-stranded deoxyribonucleic acids (ssDNAs) at very low concentrations can be detected using graphene-combined nano-slot-based terahertz (THz) resonance. A combination of the resonant structure and tuned electro-optical properties of graphene can provide unprecedentedly sensitive biomolecule sensing even using very low energy THz photons, overcoming the huge scale difference of 10,000:1 between the wavelength and the size of the ssDNAs. Ultrahigh sensitivity is obtained by the significant increase in the absorption cross-section of the graphene sheet with the targeted biomolecules, induced by strong THz field enhancement at the resonance frequency inside the slots. Clearly distinguishable THz optical signals were observed between different species of ssDNAs even at the nano-mole level and analyzed quantitatively in terms of the electro-optical properties of the suspended graphene layer modified by the attached ssDNAs without any molecular-specific labeling for the THz regime. Quantitative analysis of ssDNA molecule adsorption was carried based on the change in conductivity using a theoretical THz transmission model.

AB - We report that single-stranded deoxyribonucleic acids (ssDNAs) at very low concentrations can be detected using graphene-combined nano-slot-based terahertz (THz) resonance. A combination of the resonant structure and tuned electro-optical properties of graphene can provide unprecedentedly sensitive biomolecule sensing even using very low energy THz photons, overcoming the huge scale difference of 10,000:1 between the wavelength and the size of the ssDNAs. Ultrahigh sensitivity is obtained by the significant increase in the absorption cross-section of the graphene sheet with the targeted biomolecules, induced by strong THz field enhancement at the resonance frequency inside the slots. Clearly distinguishable THz optical signals were observed between different species of ssDNAs even at the nano-mole level and analyzed quantitatively in terms of the electro-optical properties of the suspended graphene layer modified by the attached ssDNAs without any molecular-specific labeling for the THz regime. Quantitative analysis of ssDNA molecule adsorption was carried based on the change in conductivity using a theoretical THz transmission model.

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Graphene assisted terahertz metamaterials for sensitive bio-sensing

Abstract

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Keywords

ASJC Scopus subject areas

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