Graphene assisted terahertz metamaterials for sensitive bio-sensing

Sang Hun Lee, Jong Ho Choe, Chulki Kim, Sukang Bae, Jin Soo Kim, Q. Han Park, Minah Seo

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)


We report that single-stranded deoxyribonucleic acids (ssDNAs) at very low concentrations can be detected using graphene-combined nano-slot-based terahertz (THz) resonance. A combination of the resonant structure and tuned electro-optical properties of graphene can provide unprecedentedly sensitive biomolecule sensing even using very low energy THz photons, overcoming the huge scale difference of 10,000:1 between the wavelength and the size of the ssDNAs. Ultrahigh sensitivity is obtained by the significant increase in the absorption cross-section of the graphene sheet with the targeted biomolecules, induced by strong THz field enhancement at the resonance frequency inside the slots. Clearly distinguishable THz optical signals were observed between different species of ssDNAs even at the nano-mole level and analyzed quantitatively in terms of the electro-optical properties of the suspended graphene layer modified by the attached ssDNAs without any molecular-specific labeling for the THz regime. Quantitative analysis of ssDNA molecule adsorption was carried based on the change in conductivity using a theoretical THz transmission model.

Original languageEnglish
Article number127841
JournalSensors and Actuators, B: Chemical
Publication statusPublished - 2020 May 1


  • Biosensor
  • Graphene
  • Metamaterial
  • Terahertz

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Instrumentation
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Electrical and Electronic Engineering
  • Materials Chemistry


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