Group-wise registration of large image dataset by hierarchical clustering and alignment

Qian Wang, Liya Chen, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)


Group-wise registration has been proposed recently for consistent registration of all images in the same dataset. Since all images need to be registered simultaneously with lots of deformation parameters to be optimized, the number of images that the current group-wise registration methods can handle is limited due to the capability of CPU and physical memory in a general computer. To overcome this limitation, we present a hierarchical group-wise registration method for feasible registration of large image dataset. Our basic idea is to decompose the large-scale group-wise registration problem into a series of small-scale registration problems, each of which can be easily solved. In particular, we use a novel affinity propagation method to hierarchically cluster a group of images into a pyramid of classes. Then, images in the same class are group-wisely registered to their own center image. The center images of different classes are further group-wisely registered from the lower level to the upper level of the pyramid. A final atlas for the whole image dataset is thus synthesized when the registration process reaches the top of the pyramid. By applying this hierarchical image clustering and atlas synthesis strategy, we can efficiently and effectively perform group-wise registration to a large image dataset and map each image into the atlas space. More importantly, experimental results on both real and simulated data also confirm that the proposed method can achieve more robust and accurate registration than the conventional group-wise registration algorithms.

Original languageEnglish
Title of host publicationMedical Imaging 2009 - Image Processing
Publication statusPublished - 2009
Externally publishedYes
EventMedical Imaging 2009 - Image Processing - Lake Buena Vista, FL, United States
Duration: 2009 Feb 82009 Feb 10

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherMedical Imaging 2009 - Image Processing
Country/TerritoryUnited States
CityLake Buena Vista, FL


  • Group-wise registration
  • Hierarchical registration
  • Image clustering

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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