Growth factors-loaded stents modified with hyaluronic acid and heparin for induction of rapid and tight re-endothelialization

Dong Hoon Choi, Sung Nam Kang, Seong Min Kim, Samy Gobaa, Bang Ju Park, Ik Hwan Kim, Yoon Ki Joung, Dong Keun Han

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)


Rapid re-endothelialization of damaged vessel lining efficiently prevents restenosis and thrombosis and restores original vascular functions. In this study, we designed a novel metallic stent with a heparin-modified surface and used different methods, including 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and divinyl sulfone (DVS), to load growth factors. First we loaded heparin into a dopamine-conjugated hyaluronic acid (HA) coating to serve as a growth factor reservoir. In a second step, we took advantage of the heparin-binding domain of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) to gain advanced re-endothelialization capabilities. We demonstrated that DVS technique offered higher amount of growth factor loading. In vitro assessment also showed better capillary-like structure formation and localized gap junctions when DVS coating was employed. This study suggested that growth factor loaded stent modified by HA and heparin provided the advantage to rapid and tight restoration of endothelium.

Original languageEnglish
Pages (from-to)602-610
Number of pages9
JournalColloids and Surfaces B: Biointerfaces
Publication statusPublished - 2016 May 1

Bibliographical note

Funding Information:
This work was supported by Cell Regeneration Program (2013M3A9C6049717) and Pioneer Research Center Program (2014M3C1A3056052) through the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (MSIP) and Core Material (10048019) funded by Ministry of Trade, Industry and Energy (MOTIE), and KIST Program (2E25260) funded by MSIP, Republic of Korea.


  • Dopamine
  • Growth factor
  • Heparin
  • Hyaluronic acid
  • Re-endothelialization
  • Stent

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry


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