Abstract
Reduction of insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) extends the lifespan of various species. So far, several longevity mouse models have been developed containing mutations related to growth signaling deficiency by targeting growth hormone (GH), IGF1, IGF1 receptor, insulin receptor, and insulin receptor substrate. In addition, p70 ribosomal protein S6 kinase 1 (S6K1) knockout leads to lifespan extension. S6K1 encodes an important kinase in the regulation of cell growth. S6K1 is regulated by mechanistic target of rapamycin (mTOR) complex 1. The v-myc myelocytomatosis viral oncogene homolog (MYC)-deficient mice also exhibits a longevity phenotype. The gene expression profiles of these mice models have been measured to identify their longevity mechanisms. Here, we summarize our knowledge of long-lived mouse models related to growth and discuss phenotypic characteristics, including organ-specific gene expression patterns.
| Original language | English |
|---|---|
| Pages (from-to) | 70-85 |
| Number of pages | 16 |
| Journal | BMB reports |
| Volume | 52 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2019 Jan 1 |
Bibliographical note
Funding Information:This work was carried out with the support of Bio and Medical Technology Development Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (NRF-2017R1D1A1A02019355).
Publisher Copyright:
© 2019 by the The Korean Society for Biochemistry and Molecular Biology.
Keywords
- Gene expression
- Growth signaling
- Longevity
- Mouse model
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology