HAMMER: Hierarchical attribute matching mechanism for elastic registration

Dinggang Shen, Christos Davatzikos

Research output: Contribution to conferencePaperpeer-review

22 Citations (Scopus)


A new approach is presented for elastic registration of medical images, and is applied to magnetic resonance images of the brain. Experimental results demonstrate remarkably high accuracy in superposition of images from different subjects, thus enabling very precise localization of morphological characteristics in population studies. There are two major novelties in the proposed algorithm. First, it uses an attribute vector, i.e. a set of geometric moment invariants that is defined on each voxel in an image, to reflect the underlying anatomy at different scales. The attribute vector, if rich enough, can distinguish between different parts of an image, which helps establish anatomical correspondences in the deformation procedure. This is a fundamental deviation of our method, referred to as HAMMER, from other volumetric deformation methods, which are typically based on maximizing image similarity. Second, in order to avoid being trapped by local minima, i.e. suboptimal poor matches, HAMMER uses a successive approximation of the energy function being optimized by lower dimensional energy functions, which are constructed to have significantly fewer local minima. This is achieved by hierarchically selecting features that have distinct attribute vectors, thus drastically reducing ambiguity in finding correspondence. A number of experiments in this paper have demonstrated excellent performance.

Original languageEnglish
Number of pages8
Publication statusPublished - 2001
Externally publishedYes
EventWorkshop on Mathematical Methods in Biomedical Image Analysis MMBIA 2001 - Kauai, HI, United States
Duration: 2001 Dec 92001 Dec 10


OtherWorkshop on Mathematical Methods in Biomedical Image Analysis MMBIA 2001
Country/TerritoryUnited States
CityKauai, HI

ASJC Scopus subject areas

  • Analysis


Dive into the research topics of 'HAMMER: Hierarchical attribute matching mechanism for elastic registration'. Together they form a unique fingerprint.

Cite this