Hantaviruses: Rediscovery and new beginnings

Richard Yanagihara, Se Hun Gu, Satoru Arai, Hae Ji Kang, Jin Won Song

    Research output: Contribution to journalArticlepeer-review

    97 Citations (Scopus)

    Abstract

    Virus and host gene phylogenies, indicating that antigenically distinct hantaviruses (family Bunyaviridae, genus Hantavirus) segregate into clades, which parallel the molecular evolution of rodents belonging to the Murinae, Arvicolinae, Neotominae and Sigmodontinae subfamilies, suggested co-divergence of hantaviruses and their rodent reservoirs. Lately, this concept has been vigorously contested in favor of preferential host switching and local host-specific adaptation. To gain insights into the host range, spatial and temporal distribution, genetic diversity and evolutionary origins of hantaviruses, we employed reverse transcription-polymerase chain reaction to analyze frozen, RNAlater®-preserved and ethanol-fixed tissues from 1546 shrews (9 genera and 47 species), 281 moles (8 genera and 10 species) and 520 bats (26 genera and 53 species), collected in Europe, Asia, Africa and North America during 1980-2012. Thus far, we have identified 24 novel hantaviruses in shrews, moles and bats. That these newfound hantaviruses are geographically widespread and genetically more diverse than those harbored by rodents suggests that the evolutionary history of hantaviruses is far more complex than previously conjectured. Phylogenetic analyses indicate four distinct clades, with the most divergent comprising hantaviruses harbored by the European mole and insectivorous bats, with evidence for both co-divergence and host switching. Future studies will provide new knowledge about the transmission dynamics and pathogenic potential of these newly discovered, still-orphan, non-rodent-borne hantaviruses.

    Original languageEnglish
    Pages (from-to)6-14
    Number of pages9
    JournalVirus Research
    Volume187
    DOIs
    Publication statusPublished - 2014 Jul 17

    Bibliographical note

    Funding Information:
    The collaborative contributions of the following individuals are gratefully acknowledged: Sergey A. Abramov, Luck Ju Baek, Shannon N. Bennett, Chris Conroy, Joseph A. Cook, Christiane Denys, Laurie Dizney, Paul E. Doetsch, Sylvain Dubey, Jake A. Esselstyn, Andrew G. Hope, Janusz Hejduk, Monika Hilbe, Jean-Pierre Hugot, Francois Jacquet, Blaise Kadjo, Michael Y. Kosoy, Takeshi Kurata, Eileen Lacey, Aude Lalis, Pawel P. Liberski, Burton K. Lim, Janusz Markowski, Shigeru Morikawa, Vivek R. Nerurkar, Violaine Nicolas, Satoshi D. Ohdachi, Nobuhiko Okabe, Maria Puorger, Luis A. Ruedas, Nuankanya Sathirapongsasuti, Beata Sikorska, Ki-Joon Song, William T. Stanley, Laarni Sumibcay, Ninh U. Truong, Thang T. Truong, Liudmila N. Yashina and Hon-Tsen Yu. This work was supported in part by the National Institutes of Health (grants R01AI075057 and P20GM103516 ) and the Japan Society for the Promotion of Science (grant 24405045 ) and the Agency for Defense Development of Korea ( UE134020ID ).

    Keywords

    • Chiroptera
    • Evolution
    • Hantavirus
    • Soricomorpha

    ASJC Scopus subject areas

    • Virology
    • Infectious Diseases
    • Cancer Research

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