Haplotype association of the MAP2K5 gene with antipsychotics-induced symptoms of restless legs syndrome among patients with schizophrenia

Seung Gul Kang, Yu Jin Lee, Young Min Park, Leen Kim, Heon Jeong Lee

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Objective Restless legs syndrome (RLS) is considered a genetic disease and, following a genome-wide association study conducted in 2007, the mitogen-activated protein kinase 5 (MAP2K5) gene has been regarded as the promising candidate gene for RLS. The present study investigated whether polymorphisms of MAP2K5 are associated with antipsychotics-induced RLS in schizophrenia. Methods We assessed antipsychotics-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group. Five single-nucleotide polymorphisms (SNPs) of MAP2K5 were genotyped. We investigated genetic and haplotypic associations of these five SNPs with the risk of antipsychotics-induced RLS symptoms. Results We divided the 190 subjects into 2 groups: 1) those with RLS symptoms (n=96) and 2) those without RLS symptoms (n=94). There were no significant intergroup differences in the distributions of the genotypes and alleles of the rs1026732, rs11635424, rs12593813, rs4489954, and rs3784709 SNPs. However, the haplotype analysis showed that the G-G-G-G-T (rs1026732-rs11635424-rs12593813-rs4489954-rs3784709) haplotype was associated with RLS symptoms (permutation p=0.033). Conclusion These data suggest that a haplotype of MAP2K5 polymorphisms confers increased susceptibility to antipsychotics-induced RLS symptoms in schizophrenic patients.

Original languageEnglish
Pages (from-to)84-89
Number of pages6
JournalPsychiatry Investigation
Issue number1
Publication statusPublished - 2018 Jan

Bibliographical note

Funding Information:
This study was supported by the Otsuka schizophrenia research fund for the young investigator of the Korea Society for Schizophrenia Research.

Publisher Copyright:
© 2018 Korean Neuropsychiatric Association.


  • Antipsychotics
  • Haplotype
  • Legs syndrome
  • MAP2K5
  • Polymorphism
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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