TY - JOUR
T1 - Heart failure with preserved ejection fraction
T2 - Insights from recent clinical researches
AU - Kim, Mi Na
AU - Park, Seong Mi
N1 - Publisher Copyright:
© 2020 The Korean Association of Internal Medicine.
PY - 2020/5
Y1 - 2020/5
N2 - Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for nearly half of the cases of HF and its incidence might be increasing with the aging society. Patients with HFpEF present with significant symptoms, including exercise intolerance, impaired quality of life, and have a poor prognosis as well as frequent hospitalization and increased mortality compared with HF with reduced ejection fraction. The concept of HFpEF is still evolving and may be a virtual complex rather than a real systemic disorder. Thus, beyond solely targeting cardiac abnormalities management strategies need to be extended, such as left ventricular diastolic dysfunction. In this review, we examine new diagnostic algorithms, pathophysiology, current management status, and ongoing trials based on heterogeneous pathophysiology and etiology in HFpEF.
AB - Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for nearly half of the cases of HF and its incidence might be increasing with the aging society. Patients with HFpEF present with significant symptoms, including exercise intolerance, impaired quality of life, and have a poor prognosis as well as frequent hospitalization and increased mortality compared with HF with reduced ejection fraction. The concept of HFpEF is still evolving and may be a virtual complex rather than a real systemic disorder. Thus, beyond solely targeting cardiac abnormalities management strategies need to be extended, such as left ventricular diastolic dysfunction. In this review, we examine new diagnostic algorithms, pathophysiology, current management status, and ongoing trials based on heterogeneous pathophysiology and etiology in HFpEF.
KW - Heart failure
KW - Preserved ejection fraction
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=85084567071&partnerID=8YFLogxK
U2 - 10.3904/kjim.2020.104
DO - 10.3904/kjim.2020.104
M3 - Review article
C2 - 32392659
AN - SCOPUS:85084567071
SN - 0494-4712
VL - 35
SP - 514
EP - 534
JO - Korean Journal of Internal Medicine
JF - Korean Journal of Internal Medicine
IS - 3
ER -