Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer

Dae Hee Lee, Suk Young Lee, Sang Cheul Oh

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)


The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers. Currently, there is no target molecular drug that clinically affects sonic hedgehog activation in patients with gastric cancer. In this review, we will focus on the current clinical treatment options for advanced gastric cancer and discuss the sonic hedgehog signaling pathway. We also review our understanding of the role of sonic hedgehog signaling in advanced gastric cancer progression. Finally, we will describe current known molecular pathways that crosstalk with the sonic hedgehog pathway in cancer stem cells.

Original languageEnglish
JournalTumor Biology
Issue number6
Publication statusPublished - 2017 Jan 1

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the Brain Korea (BK) 21 Plus Program and the grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) and funded by the Ministry of Health and Welfare(MOHW), Republic of Korea (grant number: HI15C1665).

Publisher Copyright:
© The Author(s) 2017.


  • Advanced gastric cancer
  • Cancer stem cells
  • Chemotherapy
  • Sonic hedgehog
  • Target therapy

ASJC Scopus subject areas

  • Cancer Research


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