Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer

Dae Hee Lee; Suk Young Lee; Sang Cheul Oh

doi:10.1177/1010428317692266

Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer

Dae Hee Lee, Suk Young Lee, Sang Cheul Oh

Department of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

13 Citations (Scopus)

Abstract

The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers. Currently, there is no target molecular drug that clinically affects sonic hedgehog activation in patients with gastric cancer. In this review, we will focus on the current clinical treatment options for advanced gastric cancer and discuss the sonic hedgehog signaling pathway. We also review our understanding of the role of sonic hedgehog signaling in advanced gastric cancer progression. Finally, we will describe current known molecular pathways that crosstalk with the sonic hedgehog pathway in cancer stem cells.

Original language	English
Journal	Tumor Biology
Volume	39
Issue number	6
DOIs	https://doi.org/10.1177/1010428317692266
Publication status	Published - 2017 Jan 1

Keywords

Advanced gastric cancer
Cancer stem cells
Chemotherapy
Sonic hedgehog
Target therapy

ASJC Scopus subject areas

Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1010428317692266

Cite this

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title = "Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer",

abstract = "The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers. Currently, there is no target molecular drug that clinically affects sonic hedgehog activation in patients with gastric cancer. In this review, we will focus on the current clinical treatment options for advanced gastric cancer and discuss the sonic hedgehog signaling pathway. We also review our understanding of the role of sonic hedgehog signaling in advanced gastric cancer progression. Finally, we will describe current known molecular pathways that crosstalk with the sonic hedgehog pathway in cancer stem cells.",

keywords = "Advanced gastric cancer, Cancer stem cells, Chemotherapy, Sonic hedgehog, Target therapy",

author = "Lee, {Dae Hee} and Lee, {Suk Young} and Oh, {Sang Cheul}",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the Brain Korea (BK) 21 Plus Program and the grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) and funded by the Ministry of Health and Welfare(MOHW), Republic of Korea (grant number: HI15C1665). Publisher Copyright: {\textcopyright} The Author(s) 2017.",

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doi = "10.1177/1010428317692266",

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AU - Lee, Suk Young

AU - Oh, Sang Cheul

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the Brain Korea (BK) 21 Plus Program and the grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) and funded by the Ministry of Health and Welfare(MOHW), Republic of Korea (grant number: HI15C1665). Publisher Copyright: © The Author(s) 2017.

PY - 2017/1/1

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N2 - The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers. Currently, there is no target molecular drug that clinically affects sonic hedgehog activation in patients with gastric cancer. In this review, we will focus on the current clinical treatment options for advanced gastric cancer and discuss the sonic hedgehog signaling pathway. We also review our understanding of the role of sonic hedgehog signaling in advanced gastric cancer progression. Finally, we will describe current known molecular pathways that crosstalk with the sonic hedgehog pathway in cancer stem cells.

AB - The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers. Currently, there is no target molecular drug that clinically affects sonic hedgehog activation in patients with gastric cancer. In this review, we will focus on the current clinical treatment options for advanced gastric cancer and discuss the sonic hedgehog signaling pathway. We also review our understanding of the role of sonic hedgehog signaling in advanced gastric cancer progression. Finally, we will describe current known molecular pathways that crosstalk with the sonic hedgehog pathway in cancer stem cells.

KW - Advanced gastric cancer

KW - Cancer stem cells

KW - Chemotherapy

KW - Sonic hedgehog

KW - Target therapy

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DO - 10.1177/1010428317692266

M3 - Review article

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AN - SCOPUS:85021859382

SN - 1010-4283

VL - 39

JO - Tumor Biology

JF - Tumor Biology

IS - 6

ER -

Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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