Hemodynamic correlation imaging of the mouse brain for application in unilateral neurodegenerative diseases

Seung Ho Paik, Sedef Erdogan, Zephaniah Phillips V, Youngkyu Kim, Kang Il Song, Sunghee Estelle Park, Youngwoon Choi, Inchan Youn, Beop Min Kim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


We developed a single-camera two-channel hemodynamic imaging system that uses near-infrared light to monitor the mouse brain in vivo with an exposed, un-thinned, and intact skull to explore the effect of Parkinson’s disease on the resting state functional connectivity of the brain. To demonstrate our system’s ability to monitor cerebral hemodynamics, we first performed direct electrical stimulation of an anesthetized healthy mouse brain and detected hemodynamic changes localized to the stimulated area. Subsequently, we developed a unilaterally lesioned 6-hydroxydopamine (hemi-parkinsonian) mouse model and detected the differences in functional connectivity between the normal and hemi-parkinsonian mouse brains by comparing the hemispheric hemodynamic correlations during the resting state. Seed-based correlation for the oxy-hemoglobin channel from the left and right hemispheres of healthy mice was much higher and more symmetric than in hemi-parkinsonian mice. Through a k-means clustering of the hemodynamic signals, the healthy mouse brains were segmented according to brain region, but the hemi-parkinsonian mice did not show a similar segmentation. Overall, this study highlights the development of a spatial multiplexing hemodynamic imaging system that reveals the resting state hemodynamic connectivity in healthy and hemi-parkinsonian mice.

Original languageEnglish
Article number#349727
Pages (from-to)1736-1749
Number of pages14
JournalBiomedical Optics Express
Issue number4
Publication statusPublished - 2019 Apr 1

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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