Heparin immobilized small intestinal submucosa for cardiovascular applications

Kyoung Soo Jee; Jin Woo Bae; Jae Seung Shin; Dong Keun Han; Ki Dong Park

doi:10.1002/masy.200750320

Heparin immobilized small intestinal submucosa for cardiovascular applications

Kyoung Soo Jee, Jin Woo Bae, Jae Seung Shin, Dong Keun Han, Ki Dong Park

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A novel chemical modification of biological tissue was developed by the immobilization of heparin to small intestinal submucosa (SIS) using glutaraldehyde (GA). Heparinized SIS tissue was characterized by measuring /n vitro plasma protein adsorption, platelet adhesion, in vitro fibroblast attachment, and in vivo calcification. Lower protein adsorption and platelet adhesion were observed on heparinized SIS than non-modified SIS. The attachment of human dermal fibroblast on the heparinized SIS was significantly increased, and the amount of calcium deposited on the modified SIS was much less than fresh SIS. These results demonstrated that heparin immobilized SIS can be applied as a novel bioprosthesis for a variety of cardiovascular applications.

Original language	English
Pages (from-to)	120-123
Number of pages	4
Journal	Macromolecular Symposia
Volume	249-250
DOIs	https://doi.org/10.1002/masy.200750320
Publication status	Published - 2007
Externally published	Yes

Keywords

Bioprosthesis
Cardiovascular application
Glutaraldehyde
Heparin
Small intestinal submucosa

ASJC Scopus subject areas

Condensed Matter Physics
Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1002/masy.200750320

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title = "Heparin immobilized small intestinal submucosa for cardiovascular applications",

abstract = "A novel chemical modification of biological tissue was developed by the immobilization of heparin to small intestinal submucosa (SIS) using glutaraldehyde (GA). Heparinized SIS tissue was characterized by measuring /n vitro plasma protein adsorption, platelet adhesion, in vitro fibroblast attachment, and in vivo calcification. Lower protein adsorption and platelet adhesion were observed on heparinized SIS than non-modified SIS. The attachment of human dermal fibroblast on the heparinized SIS was significantly increased, and the amount of calcium deposited on the modified SIS was much less than fresh SIS. These results demonstrated that heparin immobilized SIS can be applied as a novel bioprosthesis for a variety of cardiovascular applications.",

keywords = "Bioprosthesis, Cardiovascular application, Glutaraldehyde, Heparin, Small intestinal submucosa",

author = "Jee, {Kyoung Soo} and Bae, {Jin Woo} and Shin, {Jae Seung} and Han, {Dong Keun} and Park, {Ki Dong}",

year = "2007",

doi = "10.1002/masy.200750320",

language = "English",

volume = "249-250",

pages = "120--123",

journal = "Macromolecular Symposia",

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T1 - Heparin immobilized small intestinal submucosa for cardiovascular applications

AU - Jee, Kyoung Soo

AU - Bae, Jin Woo

AU - Shin, Jae Seung

AU - Han, Dong Keun

AU - Park, Ki Dong

PY - 2007

Y1 - 2007

N2 - A novel chemical modification of biological tissue was developed by the immobilization of heparin to small intestinal submucosa (SIS) using glutaraldehyde (GA). Heparinized SIS tissue was characterized by measuring /n vitro plasma protein adsorption, platelet adhesion, in vitro fibroblast attachment, and in vivo calcification. Lower protein adsorption and platelet adhesion were observed on heparinized SIS than non-modified SIS. The attachment of human dermal fibroblast on the heparinized SIS was significantly increased, and the amount of calcium deposited on the modified SIS was much less than fresh SIS. These results demonstrated that heparin immobilized SIS can be applied as a novel bioprosthesis for a variety of cardiovascular applications.

AB - A novel chemical modification of biological tissue was developed by the immobilization of heparin to small intestinal submucosa (SIS) using glutaraldehyde (GA). Heparinized SIS tissue was characterized by measuring /n vitro plasma protein adsorption, platelet adhesion, in vitro fibroblast attachment, and in vivo calcification. Lower protein adsorption and platelet adhesion were observed on heparinized SIS than non-modified SIS. The attachment of human dermal fibroblast on the heparinized SIS was significantly increased, and the amount of calcium deposited on the modified SIS was much less than fresh SIS. These results demonstrated that heparin immobilized SIS can be applied as a novel bioprosthesis for a variety of cardiovascular applications.

KW - Bioprosthesis

KW - Cardiovascular application

KW - Glutaraldehyde

KW - Heparin

KW - Small intestinal submucosa

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DO - 10.1002/masy.200750320

M3 - Article

AN - SCOPUS:34547162931

SN - 1022-1360

VL - 249-250

SP - 120

EP - 123

JO - Macromolecular Symposia

JF - Macromolecular Symposia

ER -

Heparin immobilized small intestinal submucosa for cardiovascular applications

Abstract

Keywords

ASJC Scopus subject areas

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