Hepatokines as a link between obesity and cardiovascular diseases

Hye Jin Yoo, Kyung Mook Choi

Research output: Contribution to journalReview articlepeer-review

64 Citations (Scopus)


Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence suggests that a group of predominantly liver-derived proteins called hepatokines directly affect the progression of atherosclerosis by modulating endothelial dysfunction and infiltration of inflammatory cells into vessel walls. Here, we summarize the role of the representative hepatokines fibroblast growth factor 21, fetuin-A, and selenoprotein P in the progression of CVD.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalDiabetes and Metabolism Journal
Issue number1
Publication statusPublished - 2015


  • Fetuin-A
  • Fibroblast growth factor 21
  • Hepatokines
  • Non-alcoholic fatty liver disease
  • Selenoprotein P

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism


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