HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery

Hoyeon Lee; Soojin Uhm; Jung Won Shin; Hyun Mi Jeon; Sun Dongbang; Hyo Sung Jung; Yun Cheol Na; Chulhun Kang; Jong Seung Kim

doi:10.1002/asia.201500913

HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery

Hoyeon Lee, Soojin Uhm, Jung Won Shin, Hyun Mi Jeon, Sun Dongbang, Hyo Sung Jung, Yun Cheol Na, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

A galactose-appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy. Try to resist: The study of HepG2 cell resistance against camptothecin (CPT) using a galactose-appended drug delivery system was successfully performed. The system released CPT to lysosomes of HepG2 hepatoma cells so that the lysosomal release of CPT led to the cell resistance to the anticancer drug.

Original language	English
Pages (from-to)	2695-2700
Number of pages	6
Journal	Chemistry - An Asian Journal
Volume	10
Issue number	12
DOIs	https://doi.org/10.1002/asia.201500913
Publication status	Published - 2015 Dec 1

Keywords

anticancer drugs
camptothecin
cancer
drug delivery
galactose

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/asia.201500913

Cite this

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title = "HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery",

abstract = "A galactose-appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy. Try to resist: The study of HepG2 cell resistance against camptothecin (CPT) using a galactose-appended drug delivery system was successfully performed. The system released CPT to lysosomes of HepG2 hepatoma cells so that the lysosomal release of CPT led to the cell resistance to the anticancer drug.",

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author = "Hoyeon Lee and Soojin Uhm and Shin, {Jung Won} and Jeon, {Hyun Mi} and Sun Dongbang and Jung, {Hyo Sung} and Na, {Yun Cheol} and Chulhun Kang and Kim, {Jong Seung}",

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doi = "10.1002/asia.201500913",

language = "English",

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AU - Lee, Hoyeon

AU - Uhm, Soojin

AU - Shin, Jung Won

AU - Jeon, Hyun Mi

AU - Dongbang, Sun

AU - Jung, Hyo Sung

AU - Na, Yun Cheol

AU - Kang, Chulhun

AU - Kim, Jong Seung

PY - 2015/12/1

Y1 - 2015/12/1

N2 - A galactose-appended drug delivery system released camptothecin (CPT) to lysosomes of HepG2 hepatoma cells, resulting in the cell resistance to the anticancer drug. We found that the resistance to CPT is caused by alteration of the drug release from the prodrug in lysosomes, emphasizing that the final delivery locations may critically influence drug efficacy. Try to resist: The study of HepG2 cell resistance against camptothecin (CPT) using a galactose-appended drug delivery system was successfully performed. The system released CPT to lysosomes of HepG2 hepatoma cells so that the lysosomal release of CPT led to the cell resistance to the anticancer drug.

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KW - cancer

KW - drug delivery

KW - galactose

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HepG2 Cell Resistance against Camptothecin from a Lysosomal Drug Delivery

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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