Hetero-Integration of Silicon Nanomembranes with 2D Materials for Bioresorbable, Wireless Neurochemical System

Seung Min Yang, Jae Hyung Shim, Hyun U. Cho, Tae Min Jang, Gwan Jin Ko, Jeongeun Shim, Tae Hee Kim, Jia Zhu, Sangun Park, Yoon Seok Kim, Su Yeon Joung, Jong Chan Choe, Jeong Woong Shin, Joong Hoon Lee, Yu Min Kang, Huanyu Cheng, Youngmee Jung, Chul Ho Lee, Dong Pyo Jang, Suk Won Hwang

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)


Although neurotransmitters are key substances closely related to evaluating degenerative brain diseases as well as regulating essential functions in the body, many research efforts have not been focused on direct observation of such biochemical messengers, rather on monitoring relatively associated physical, mechanical, and electrophysiological parameters. Here, a bioresorbable silicon-based neurochemical analyzer incorporated with 2D transition metal dichalcogenides is introduced as a completely implantable brain-integrated system that can wirelessly monitor time-dynamic behaviors of dopamine and relevant parameters in a simultaneous mode. An extensive range of examinations of molybdenum/tungsten disulfide (MoS2/WS2) nanosheets and catalytic iron nanoparticles (Fe NPs) highlights the underlying mechanisms of strong chemical and target-specific responses to the neurotransmitters, along with theoretical modeling tools. Systematic characterizations demonstrate reversible, stable, and long-term operational performances of the degradable bioelectronics with excellent sensitivity and selectivity over those of non-dissolvable counterparts. A complete set of in vivo experiments with comparative analysis using carbon-fiber electrodes illustrates the capability for potential use as a clinically accessible tool to associated neurodegenerative diseases.

Original languageEnglish
Article number2108203
JournalAdvanced Materials
Issue number14
Publication statusPublished - 2022 Apr 7

Bibliographical note

Publisher Copyright:
© 2022 Wiley-VCH GmbH.


  • 2D materials
  • bioresorbable materials
  • neurochemical systems
  • silicon nanomembranes

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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