Abstract
The silica gel-supported bis-cinchona alkaloid 1a was prepared and found to be an efficient heterogeneous chiral organocatalyst with high catalytic activities, enantioselectivities (up to 92% ee), and recyclability for the asymmetric desymmetrization of meso-cyclic anhydrides with alcoholysis. Graphical Abstract
Original language | English |
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Pages (from-to) | 12051-12057 |
Number of pages | 7 |
Journal | Tetrahedron |
Volume | 60 |
Issue number | 52 |
DOIs | |
Publication status | Published - 2004 Dec 20 |
Keywords
- Asymmetric organocatalysis
- Cinchona alkaloid
- Cyclic anhydride
- Desymmetrization
- Heterogeneous chiral organocatalyst
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry