Heterologous production of 4- O -demethylbarbamide, a marine cyanobacterial natural product

Eun Ji Kim, Jong Hyun Lee, Hyukjae Choi, Alban R. Pereira, Yeon Hee Ban, Young Ji Yoo, Eunji Kim, Je Won Park, David H. Sherman, William H. Gerwick, Yeo Joon Yoon

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.

Original languageEnglish
Pages (from-to)5824-5827
Number of pages4
JournalOrganic Letters
Issue number23
Publication statusPublished - 2012 Dec 7
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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