Heterologous production of 4- O -demethylbarbamide, a marine cyanobacterial natural product

Eun Ji Kim; Jong Hyun Lee; Hyukjae Choi; Alban R. Pereira; Yeon Hee Ban; Young Ji Yoo; Eunji Kim; Je Won Park; David H. Sherman; William H. Gerwick; Yeo Joon Yoon

doi:10.1021/ol302575h

Heterologous production of 4- O -demethylbarbamide, a marine cyanobacterial natural product

Eun Ji Kim
, Jong Hyun Lee
, Hyukjae Choi
, Alban R. Pereira
, Yeon Hee Ban
, Young Ji Yoo
, Eunji Kim
, Je Won Park
, David H. Sherman
, William H. Gerwick^*
, Yeo Joon Yoon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Abstract

Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.

Original language	English
Pages (from-to)	5824-5827
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	23
DOIs	https://doi.org/10.1021/ol302575h
Publication status	Published - 2012 Dec 7
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/ol302575h

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title = "Heterologous production of 4- O -demethylbarbamide, a marine cyanobacterial natural product",

abstract = "Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.",

author = "Kim, \{Eun Ji\} and Lee, \{Jong Hyun\} and Hyukjae Choi and Pereira, \{Alban R.\} and Ban, \{Yeon Hee\} and Yoo, \{Young Ji\} and Eunji Kim and Park, \{Je Won\} and Sherman, \{David H.\} and Gerwick, \{William H.\} and Yoon, \{Yeo Joon\}",

year = "2012",

month = dec,

day = "7",

doi = "10.1021/ol302575h",

language = "English",

volume = "14",

pages = "5824--5827",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Heterologous production of 4- O -demethylbarbamide, a marine cyanobacterial natural product

AU - Kim, Eun Ji

AU - Lee, Jong Hyun

AU - Choi, Hyukjae

AU - Pereira, Alban R.

AU - Ban, Yeon Hee

AU - Yoo, Young Ji

AU - Kim, Eunji

AU - Park, Je Won

AU - Sherman, David H.

AU - Gerwick, William H.

AU - Yoon, Yeo Joon

PY - 2012/12/7

Y1 - 2012/12/7

N2 - Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.

AB - Heterologous expression of the barbamide biosynthetic gene cluster, obtained from the marine cyanobacterium Moorea producens, in the terrestrial actinobacterium Streptomyces venezuelae, resulted in the production of a new barbamide congener 4-O-demethylbarbamide, demonstrating the potential of this approach for investigating the assembly and tailoring of complex marine natural products.

UR - https://www.scopus.com/pages/publications/84870858767

U2 - 10.1021/ol302575h

DO - 10.1021/ol302575h

M3 - Article

C2 - 23148802

AN - SCOPUS:84870858767

SN - 1523-7060

VL - 14

SP - 5824

EP - 5827

JO - Organic Letters

JF - Organic Letters

IS - 23

ER -

Heterologous production of 4- O -demethylbarbamide, a marine cyanobacterial natural product

Abstract

ASJC Scopus subject areas

UN SDGs

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