Heteronuclear Gd- 99mTc complex of DTPA-bis(histidylamide) conjugate as a bimodal MR/SPECT imaging probe

Ji Ae Park, Jung Young Kim, Hee Kyung Kim, Wonho Lee, Sang Moo Lim, Yongmin Chang, Tae Jeong Kim, Kyeong Min Kim

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Scopus)

    Abstract

    The work describes the synthesis and in vivo application of heterotrimetallic complexes of the type {Gd(H 2O)[(M(H 2O)(CO) 3) 2(1)]} {1 = DTPA-bis(histidyl-amide); M = Re (3a); 99mTc (3b)} for dual modality MR/SPECT imaging. Here, the DTPA-bis(histidylamide) conjugate functions as a trinucleating chelate incorporating Gd in the DTPA core with Re or 99mTc in the pair of histidylamide side arms. The two complexes are chemically equivalent as revealed by HPLC, and their "cocktail mixture" (3a + 3b) has demonstrated itself to be essentially a single bimodal imaging probe. The present system has thus overcome the sensitivity difference problem between MRI and SPECT and paved the way for practical applications.

    Original languageEnglish
    Pages (from-to)299-302
    Number of pages4
    JournalACS Medicinal Chemistry Letters
    Volume3
    Issue number4
    DOIs
    Publication statusPublished - 2012 Apr 12

    Keywords

    • MR/SPECT
    • cocktail mixture
    • dual modality
    • heterotrimetallic Gd-[ Tc] /[Re] complexes
    • imaging probe

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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