High hydrostatic pressure extract of red ginseng attenuates inflammation in rats with high-fat diet induced obesity

Sunyoon Jung, Mak Soon Lee, Yoonjin Shin, Chong Tai Kim, In Hwan Kim, Yangha Kim

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Chronic low-grade inflammation is associated with obesity. This study investigated effect of high hydrostatic pressure extract of red ginseng (HRG) on inflammation in rats with high-fat (HF) diet induced obesity. Male, Sprague-Dawley rats (80∼110 g) were randomly divided into two groups, and fed a 45% HF diet (HF) and a 45% HF diet containing 1.5% HRG (HF+HRG) for 14 weeks. At the end of the experiment, the serum leptin level was reduced by the HRG supplementation. The mRNA expression of genes related to adipogenesis including peroxisome proliferator-activated receptorgamma and adipocyte protein 2 was down-regulated in the white adipose tissue (WAT). The mRNA levels of major inflammatory cytokines such as tumor necrosis factor-α, monocyte chemoattractant protein 1, and interleukin-6 were remarkably down-regulated by the HRG in WAT. These results suggest that HRG might be beneficial in ameliorating the inflammation-associated health complications by suppressing adipogenic and pro-inflammatory gene expression.

    Original languageEnglish
    Pages (from-to)253-259
    Number of pages7
    JournalPreventive Nutrition and Food Science
    Volume20
    Issue number4
    DOIs
    Publication statusPublished - 2015 Dec

    Bibliographical note

    Funding Information:
    This study was supported by the Food High Pressure Technology Development Project, the Korea Food Research Institute (No. 202007-03-03-WT011), the National Research Foundation of Korea (NRF) funded by the Korean Government (MOE) (No. 2013R1A1A2009522), and BK21 Plus (22A20130012143).

    Publisher Copyright:
    Copyright © 2015 by The Korean Society of Food Science and Nutrition. All rights Reserved.

    Keywords

    • Gene expression
    • High hydrostatic pressure
    • High-fat diet
    • Inflammation
    • Red ginseng

    ASJC Scopus subject areas

    • Food Science
    • Nutrition and Dietetics

    Fingerprint

    Dive into the research topics of 'High hydrostatic pressure extract of red ginseng attenuates inflammation in rats with high-fat diet induced obesity'. Together they form a unique fingerprint.

    Cite this