Abstract
Chronic low-grade inflammation is associated with obesity. This study investigated effect of high hydrostatic pressure extract of red ginseng (HRG) on inflammation in rats with high-fat (HF) diet induced obesity. Male, Sprague-Dawley rats (80∼110 g) were randomly divided into two groups, and fed a 45% HF diet (HF) and a 45% HF diet containing 1.5% HRG (HF+HRG) for 14 weeks. At the end of the experiment, the serum leptin level was reduced by the HRG supplementation. The mRNA expression of genes related to adipogenesis including peroxisome proliferator-activated receptorgamma and adipocyte protein 2 was down-regulated in the white adipose tissue (WAT). The mRNA levels of major inflammatory cytokines such as tumor necrosis factor-α, monocyte chemoattractant protein 1, and interleukin-6 were remarkably down-regulated by the HRG in WAT. These results suggest that HRG might be beneficial in ameliorating the inflammation-associated health complications by suppressing adipogenic and pro-inflammatory gene expression.
| Original language | English |
|---|---|
| Pages (from-to) | 253-259 |
| Number of pages | 7 |
| Journal | Preventive Nutrition and Food Science |
| Volume | 20 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2015 Dec |
Bibliographical note
Funding Information:This study was supported by the Food High Pressure Technology Development Project, the Korea Food Research Institute (No. 202007-03-03-WT011), the National Research Foundation of Korea (NRF) funded by the Korean Government (MOE) (No. 2013R1A1A2009522), and BK21 Plus (22A20130012143).
Publisher Copyright:
Copyright © 2015 by The Korean Society of Food Science and Nutrition. All rights Reserved.
Keywords
- Gene expression
- High hydrostatic pressure
- High-fat diet
- Inflammation
- Red ginseng
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics
