High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs

Jeong Hwan Kim; Seong Woo Kang; Seung Wook Kim; Hyo Ihl Chang

doi:10.1271/bbb.69.1743

High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs

Jeong Hwan Kim
, Seong Woo Kang
, Seung Wook Kim
, Hyo Ihl Chang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Medium composition was optimized for high-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs. Glucose and yeast extract were the most important factors affecting astaxanthin production. Glucose 3.89%, yeast extract 0.29%, KH ₂PO₄ 0.25%, MgSO₄ 0.05%, MnSO₄ 0.02%, and CaCl₂ 0.01% were optimum for high-level production of astaxanthin. Under optimized conditions, the maximum concentration of astaxanthin obtained after 7 d of cultivation was 36.06 mg/l. The concentration of astaxanthin predicted by a polynomial model was 36.16 mg/l.

Original language	English
Pages (from-to)	1743-1748
Number of pages	6
Journal	Bioscience, Biotechnology and Biochemistry
Volume	69
Issue number	9
DOIs	https://doi.org/10.1271/bbb.69.1743
Publication status	Published - 2005

Bibliographical note

Funding Information:
This study was supported by technology Development Program for Agriculture and Forestry, Ministry of Agriculture and Forestry, Republic of Korea.

Keywords

Astaxanthin
Carotenoids
High-level production
Statistical experimental designs
Xanthophyllomyces dendrorhous

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.69.1743

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title = "High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs",

abstract = "Medium composition was optimized for high-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs. Glucose and yeast extract were the most important factors affecting astaxanthin production. Glucose 3.89\%, yeast extract 0.29\%, KH 2PO4 0.25\%, MgSO4 0.05\%, MnSO4 0.02\%, and CaCl2 0.01\% were optimum for high-level production of astaxanthin. Under optimized conditions, the maximum concentration of astaxanthin obtained after 7 d of cultivation was 36.06 mg/l. The concentration of astaxanthin predicted by a polynomial model was 36.16 mg/l.",

keywords = "Astaxanthin, Carotenoids, High-level production, Statistical experimental designs, Xanthophyllomyces dendrorhous",

author = "Kim, \{Jeong Hwan\} and Kang, \{Seong Woo\} and Kim, \{Seung Wook\} and Chang, \{Hyo Ihl\}",

note = "Funding Information: This study was supported by technology Development Program for Agriculture and Forestry, Ministry of Agriculture and Forestry, Republic of Korea.",

year = "2005",

doi = "10.1271/bbb.69.1743",

language = "English",

volume = "69",

pages = "1743--1748",

journal = "Bioscience, Biotechnology and Biochemistry",

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T1 - High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs

AU - Kim, Jeong Hwan

AU - Kang, Seong Woo

AU - Kim, Seung Wook

AU - Chang, Hyo Ihl

N1 - Funding Information: This study was supported by technology Development Program for Agriculture and Forestry, Ministry of Agriculture and Forestry, Republic of Korea.

PY - 2005

Y1 - 2005

N2 - Medium composition was optimized for high-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs. Glucose and yeast extract were the most important factors affecting astaxanthin production. Glucose 3.89%, yeast extract 0.29%, KH 2PO4 0.25%, MgSO4 0.05%, MnSO4 0.02%, and CaCl2 0.01% were optimum for high-level production of astaxanthin. Under optimized conditions, the maximum concentration of astaxanthin obtained after 7 d of cultivation was 36.06 mg/l. The concentration of astaxanthin predicted by a polynomial model was 36.16 mg/l.

AB - Medium composition was optimized for high-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs. Glucose and yeast extract were the most important factors affecting astaxanthin production. Glucose 3.89%, yeast extract 0.29%, KH 2PO4 0.25%, MgSO4 0.05%, MnSO4 0.02%, and CaCl2 0.01% were optimum for high-level production of astaxanthin. Under optimized conditions, the maximum concentration of astaxanthin obtained after 7 d of cultivation was 36.06 mg/l. The concentration of astaxanthin predicted by a polynomial model was 36.16 mg/l.

KW - Astaxanthin

KW - Carotenoids

KW - High-level production

KW - Statistical experimental designs

KW - Xanthophyllomyces dendrorhous

UR - https://www.scopus.com/pages/publications/25844518934

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DO - 10.1271/bbb.69.1743

M3 - Article

C2 - 16195593

AN - SCOPUS:25844518934

SN - 0916-8451

VL - 69

SP - 1743

EP - 1748

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 9

ER -

High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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