High molecular weight poly(l-lactide) and its microsphere synthesized in the supercritical dimethyl ether

Cheol Soo Yoon; Hyun Deok Park; Se Yoon Kim; Soo Hyun Kim

doi:10.1002/masy.200750429

High molecular weight poly(l-lactide) and its microsphere synthesized in the supercritical dimethyl ether

Cheol Soo Yoon, Hyun Deok Park, Se Yoon Kim, Soo Hyun Kim

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The ring-opening polymerization of L-lactide initiated by stannous octoate was carried out in supercritical dimethylether(scDME) at various reaction conditions (time and temperature). The monomer conversion increased to ca. 90% on increasing the reaction time to ihr. The molecular weight of the poly(L-lactide)(PLLA) also increased to ca. 160,000 g · mol^-1 over the same period. Increasing reaction temperature from 118 to 135°C or reaction pressure from 280 to 520 bar resulted in increased monomer conversion and molecular weight. After the polymerization, PLLA microspheres were prepared in situ by using a continuous supercritical anti-solvent process without residual organic solvent.

Original language	English
Pages (from-to)	515-520
Number of pages	6
Journal	Macromolecular Symposia
Volume	249-250
DOIs	https://doi.org/10.1002/masy.200750429
Publication status	Published - 2007

Keywords

DME
Microsphere
PLLA
Polymerization
Supercritical fluid

ASJC Scopus subject areas

Condensed Matter Physics
Organic Chemistry
Polymers and Plastics
Materials Chemistry

Access to Document

10.1002/masy.200750429

Cite this

@article{1f10e5e4d70e4c238ed42f0e0746bfd8,

title = "High molecular weight poly(l-lactide) and its microsphere synthesized in the supercritical dimethyl ether",

abstract = "The ring-opening polymerization of L-lactide initiated by stannous octoate was carried out in supercritical dimethylether(scDME) at various reaction conditions (time and temperature). The monomer conversion increased to ca. 90% on increasing the reaction time to ihr. The molecular weight of the poly(L-lactide)(PLLA) also increased to ca. 160,000 g · mol-1 over the same period. Increasing reaction temperature from 118 to 135°C or reaction pressure from 280 to 520 bar resulted in increased monomer conversion and molecular weight. After the polymerization, PLLA microspheres were prepared in situ by using a continuous supercritical anti-solvent process without residual organic solvent.",

keywords = "DME, Microsphere, PLLA, Polymerization, Supercritical fluid",

author = "Yoon, {Cheol Soo} and Park, {Hyun Deok} and Kim, {Se Yoon} and Kim, {Soo Hyun}",

year = "2007",

doi = "10.1002/masy.200750429",

language = "English",

volume = "249-250",

pages = "515--520",

journal = "Macromolecular Symposia",

issn = "1022-1360",

publisher = "Wiley-VCH Verlag",

}

TY - JOUR

T1 - High molecular weight poly(l-lactide) and its microsphere synthesized in the supercritical dimethyl ether

AU - Yoon, Cheol Soo

AU - Park, Hyun Deok

AU - Kim, Se Yoon

AU - Kim, Soo Hyun

PY - 2007

Y1 - 2007

N2 - The ring-opening polymerization of L-lactide initiated by stannous octoate was carried out in supercritical dimethylether(scDME) at various reaction conditions (time and temperature). The monomer conversion increased to ca. 90% on increasing the reaction time to ihr. The molecular weight of the poly(L-lactide)(PLLA) also increased to ca. 160,000 g · mol-1 over the same period. Increasing reaction temperature from 118 to 135°C or reaction pressure from 280 to 520 bar resulted in increased monomer conversion and molecular weight. After the polymerization, PLLA microspheres were prepared in situ by using a continuous supercritical anti-solvent process without residual organic solvent.

AB - The ring-opening polymerization of L-lactide initiated by stannous octoate was carried out in supercritical dimethylether(scDME) at various reaction conditions (time and temperature). The monomer conversion increased to ca. 90% on increasing the reaction time to ihr. The molecular weight of the poly(L-lactide)(PLLA) also increased to ca. 160,000 g · mol-1 over the same period. Increasing reaction temperature from 118 to 135°C or reaction pressure from 280 to 520 bar resulted in increased monomer conversion and molecular weight. After the polymerization, PLLA microspheres were prepared in situ by using a continuous supercritical anti-solvent process without residual organic solvent.

KW - DME

KW - Microsphere

KW - PLLA

KW - Polymerization

KW - Supercritical fluid

UR - http://www.scopus.com/inward/record.url?scp=34547175242&partnerID=8YFLogxK

U2 - 10.1002/masy.200750429

DO - 10.1002/masy.200750429

M3 - Article

AN - SCOPUS:34547175242

SN - 1022-1360

VL - 249-250

SP - 515

EP - 520

JO - Macromolecular Symposia

JF - Macromolecular Symposia

ER -

High molecular weight poly(l-lactide) and its microsphere synthesized in the supercritical dimethyl ether

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this