TY - JOUR
T1 - High-sensitivity C-reactive protein in the low- and intermediate-Framingham risk score groups
T2 - Analysis with 18F-fluorodeoxyglucose positron emission tomography
AU - Yang, Sae Jeong
AU - Kim, Sungeun
AU - Choi, Hyuk Soon
AU - Kim, Tae Nyun
AU - Yoo, Hye Jin
AU - Seo, Ji A
AU - Kim, Sin Gon
AU - Kim, Nan Hee
AU - Baik, Sei-Hyun
AU - Choi, Dong Seop
AU - Choi, Kyung Mook
N1 - Funding Information:
Dr. K. M. Choi was supported by a Korea Science and Engineering Foundation grant funded by the Korean government (No. R01-2007-000-20546-0). Dr. K. M. Choi and S. H. Baik were supported by the Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea.
PY - 2013/3/10
Y1 - 2013/3/10
N2 - Objectives: To evaluate vascular inflammation according to high-sensitivity C-reactive protein (hsCRP) levels in the low- (< 10%) and intermediate- (10%-20%) Framingham risk score (FRS) groups using 18F- fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT, which reflects vascular inflammation and vulnerable atherosclerotic plaque. Methods: We measured hsCRP levels and traditional cardiovascular risk factors in 142 non-diabetic subjects without history of cardiovascular disease. To assess the vascular influence of hsCRP on each FRS category, we compared carotid intima-media thickness (CIMT), brachial-ankle pulse wave velocity (baPWV), and vascular inflammation, which was represented as the target-to-background ratio (TBR) measured using FDG-PET/CT. Results: In both low- and intermediate-FRS categories, mean TBR values in subjects with higher hsCRP levels (≥ 2 mg/L) were significantly increased compared to those with lower hsCRP levels (< 2 mg/L) (P = 0.001, P< 0.001, respectively). However, baPWV and CIMT values did not significantly differ according to hsCRP levels in the same FRS categories. Mean TBR levels positively correlated with FRS, body mass index (BMI), whereas negatively correlated with HDL-cholesterol. Multiple stepwise regression analyses showed that hsCRP, LDL-cholesterol, BMI, and insulin resistance were independently associated with mean TBR values (R2 = 0.414). Conclusions: In both intermediate and low FRS risk groups, vascular inflammation measured using FDG-PET/CT was increased in individuals with higher hsCRP levels compared to those with lower hsCRP. (Clinicaltrials.gov: NCT01022684).
AB - Objectives: To evaluate vascular inflammation according to high-sensitivity C-reactive protein (hsCRP) levels in the low- (< 10%) and intermediate- (10%-20%) Framingham risk score (FRS) groups using 18F- fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT, which reflects vascular inflammation and vulnerable atherosclerotic plaque. Methods: We measured hsCRP levels and traditional cardiovascular risk factors in 142 non-diabetic subjects without history of cardiovascular disease. To assess the vascular influence of hsCRP on each FRS category, we compared carotid intima-media thickness (CIMT), brachial-ankle pulse wave velocity (baPWV), and vascular inflammation, which was represented as the target-to-background ratio (TBR) measured using FDG-PET/CT. Results: In both low- and intermediate-FRS categories, mean TBR values in subjects with higher hsCRP levels (≥ 2 mg/L) were significantly increased compared to those with lower hsCRP levels (< 2 mg/L) (P = 0.001, P< 0.001, respectively). However, baPWV and CIMT values did not significantly differ according to hsCRP levels in the same FRS categories. Mean TBR levels positively correlated with FRS, body mass index (BMI), whereas negatively correlated with HDL-cholesterol. Multiple stepwise regression analyses showed that hsCRP, LDL-cholesterol, BMI, and insulin resistance were independently associated with mean TBR values (R2 = 0.414). Conclusions: In both intermediate and low FRS risk groups, vascular inflammation measured using FDG-PET/CT was increased in individuals with higher hsCRP levels compared to those with lower hsCRP. (Clinicaltrials.gov: NCT01022684).
KW - Atherosclerosis
KW - Framingham risk score
KW - High-sensitivity C-reactive protein
KW - Inflammation
KW - Positron emission tomography
UR - http://www.scopus.com/inward/record.url?scp=84874531706&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2011.06.054
DO - 10.1016/j.ijcard.2011.06.054
M3 - Article
C2 - 21719129
AN - SCOPUS:84874531706
SN - 0167-5273
VL - 163
SP - 277
EP - 281
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 3
ER -