High-sensitivity detection of silver ions using oligonucleotide-immobilized oscillator

Jinsung Park, Wook Choi, Kuewhan Jang, Sungsoo Na

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)


With the remarkable developments in the fields of nanoscale research and industry, nanotoxicity is gaining importance from the viewpoint of its potential impact on human health and the environment. Herein, we report on the label-free, high-sensitivity detection of Ag+, a representative nanotoxic material, by using a silver-specific nucleotide-coated oscillator. The detection is based on the measurement of the resonant frequency shift arising from constitution of the cytosine-Ag+-cytosine bonding. We amplify the resonant frequency shift by using single cytosine molecules. It is shown that a silver-specific DNA-immobilized oscillator enables the capture of silver ions at concentrations below 1nM. Remarkably, the nucleotide-based oscillator enables an insight into the coordination chemistry, which plays an important role in the early detection of toxicity. This implies that the bio-conjugated sensor could be used to set the reference point for water quality.

Original languageEnglish
Pages (from-to)471-476
Number of pages6
JournalBiosensors and Bioelectronics
Issue number1
Publication statusPublished - 2013 Mar 15

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) under Grant nos. NRF-2012-0000785 and NRF-2011-0020090 .


  • DNA-metal interaction
  • Micro-oscillator
  • Resonant frequency
  • Scanning probe microscopy
  • Silver ion

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry


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