High-sensitivity non-enzymatic glucose biosensor based on Cu(OH) 2 nanoflower electrode covered with boron-doped nanocrystalline diamond layer

Huijun Sim; Jong Hoon Kim; Seung Koo Lee; Min Jung Song; Dong Hwa Yoon; Dae Soon Lim; Suk In Hong

doi:10.1016/j.tsf.2012.08.011

High-sensitivity non-enzymatic glucose biosensor based on Cu(OH) ₂ nanoflower electrode covered with boron-doped nanocrystalline diamond layer

Huijun Sim, Jong Hoon Kim, Seung Koo Lee, Min Jung Song, Dong Hwa Yoon, Dae Soon Lim, Suk In Hong

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

A non-enzymatic biosensor was developed using boron-doped nanocrystalline diamond (BDND) based on a Cu electrode with Cu(OH) ₂ dendritic architecture. The Cu(OH) ₂ nanoflower electrode was covered with a BDND layer using an electrostatic self-assembly seeding method with nanodiamond particles and hot-filament chemical vapor deposition. X-ray diffraction and Raman spectral analysis confirmed that the BDND nanoflower electrode was synthesized onto Cu(OH) ₂ nanoflowers. Field-emission scanning electron microscope images showed that the fabricated electrodes were nanoflowers possessing large surface areas. From cyclic voltammetry, the peak currents of an BDND/Cu(OH) ₂/Cu electrode was about 7, 6.2, and 5.9 times higher than that of the Cu foil, Cu(OH) ₂/Cu, and BDND/Cu electrodes, respectively. A biosensor based on BDND/Cu(OH) ₂/Cu exhibited excellent performance for glucose detection, and it had a linear detection range of 0 to 6 mM, a correlation coefficient of 0.9994, a low detection limit of 9 μM, and a high sensitivity of 2.1592 mA mM ^{- 1} cm ^{- 1}.

Original language	English
Pages (from-to)	7219-7223
Number of pages	5
Journal	Thin Solid Films
Volume	520
Issue number	24
DOIs	https://doi.org/10.1016/j.tsf.2012.08.011
Publication status	Published - 2012 Oct 1

Bibliographical note

Funding Information:
This CRI work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MEST) (No. 2011-0000427 ).

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

Amperometric glucose sensor
Boron-doped diamond
Chemical vapor deposition
Copper hydroxide
Crystallization from solution
Nanocrystalline diamond
Nanostructures

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Surfaces and Interfaces
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1016/j.tsf.2012.08.011

Cite this

@article{234826fc573b44e48f15f8e43d36c231,

title = "High-sensitivity non-enzymatic glucose biosensor based on Cu(OH) 2 nanoflower electrode covered with boron-doped nanocrystalline diamond layer",

abstract = "A non-enzymatic biosensor was developed using boron-doped nanocrystalline diamond (BDND) based on a Cu electrode with Cu(OH) 2 dendritic architecture. The Cu(OH) 2 nanoflower electrode was covered with a BDND layer using an electrostatic self-assembly seeding method with nanodiamond particles and hot-filament chemical vapor deposition. X-ray diffraction and Raman spectral analysis confirmed that the BDND nanoflower electrode was synthesized onto Cu(OH) 2 nanoflowers. Field-emission scanning electron microscope images showed that the fabricated electrodes were nanoflowers possessing large surface areas. From cyclic voltammetry, the peak currents of an BDND/Cu(OH) 2/Cu electrode was about 7, 6.2, and 5.9 times higher than that of the Cu foil, Cu(OH) 2/Cu, and BDND/Cu electrodes, respectively. A biosensor based on BDND/Cu(OH) 2/Cu exhibited excellent performance for glucose detection, and it had a linear detection range of 0 to 6 mM, a correlation coefficient of 0.9994, a low detection limit of 9 μM, and a high sensitivity of 2.1592 mA mM - 1 cm - 1.",

keywords = "Amperometric glucose sensor, Boron-doped diamond, Chemical vapor deposition, Copper hydroxide, Crystallization from solution, Nanocrystalline diamond, Nanostructures",

author = "Huijun Sim and Kim, {Jong Hoon} and Lee, {Seung Koo} and Song, {Min Jung} and Yoon, {Dong Hwa} and Lim, {Dae Soon} and Hong, {Suk In}",

note = "Funding Information: This CRI work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MEST) (No. 2011-0000427 ). Copyright: Copyright 2012 Elsevier B.V., All rights reserved.",

year = "2012",

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doi = "10.1016/j.tsf.2012.08.011",

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T1 - High-sensitivity non-enzymatic glucose biosensor based on Cu(OH) 2 nanoflower electrode covered with boron-doped nanocrystalline diamond layer

AU - Sim, Huijun

AU - Kim, Jong Hoon

AU - Lee, Seung Koo

AU - Song, Min Jung

AU - Yoon, Dong Hwa

AU - Lim, Dae Soon

AU - Hong, Suk In

N1 - Funding Information: This CRI work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MEST) (No. 2011-0000427 ). Copyright: Copyright 2012 Elsevier B.V., All rights reserved.

PY - 2012/10/1

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N2 - A non-enzymatic biosensor was developed using boron-doped nanocrystalline diamond (BDND) based on a Cu electrode with Cu(OH) 2 dendritic architecture. The Cu(OH) 2 nanoflower electrode was covered with a BDND layer using an electrostatic self-assembly seeding method with nanodiamond particles and hot-filament chemical vapor deposition. X-ray diffraction and Raman spectral analysis confirmed that the BDND nanoflower electrode was synthesized onto Cu(OH) 2 nanoflowers. Field-emission scanning electron microscope images showed that the fabricated electrodes were nanoflowers possessing large surface areas. From cyclic voltammetry, the peak currents of an BDND/Cu(OH) 2/Cu electrode was about 7, 6.2, and 5.9 times higher than that of the Cu foil, Cu(OH) 2/Cu, and BDND/Cu electrodes, respectively. A biosensor based on BDND/Cu(OH) 2/Cu exhibited excellent performance for glucose detection, and it had a linear detection range of 0 to 6 mM, a correlation coefficient of 0.9994, a low detection limit of 9 μM, and a high sensitivity of 2.1592 mA mM - 1 cm - 1.

AB - A non-enzymatic biosensor was developed using boron-doped nanocrystalline diamond (BDND) based on a Cu electrode with Cu(OH) 2 dendritic architecture. The Cu(OH) 2 nanoflower electrode was covered with a BDND layer using an electrostatic self-assembly seeding method with nanodiamond particles and hot-filament chemical vapor deposition. X-ray diffraction and Raman spectral analysis confirmed that the BDND nanoflower electrode was synthesized onto Cu(OH) 2 nanoflowers. Field-emission scanning electron microscope images showed that the fabricated electrodes were nanoflowers possessing large surface areas. From cyclic voltammetry, the peak currents of an BDND/Cu(OH) 2/Cu electrode was about 7, 6.2, and 5.9 times higher than that of the Cu foil, Cu(OH) 2/Cu, and BDND/Cu electrodes, respectively. A biosensor based on BDND/Cu(OH) 2/Cu exhibited excellent performance for glucose detection, and it had a linear detection range of 0 to 6 mM, a correlation coefficient of 0.9994, a low detection limit of 9 μM, and a high sensitivity of 2.1592 mA mM - 1 cm - 1.

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