Highly Enantioselective Additions of Diethylzinc to Aldehydes Using 2-Triflamido-methyl-2′-hydroxy-1 ,1′-binaphthyl

Seung Wan Kang; Dong Hyun Ko; Kyoung Hoon Kim; Deok Chan Ha

doi:10.1021/ol0358511

Highly Enantioselective Additions of Diethylzinc to Aldehydes Using 2-Triflamido-methyl-2′-hydroxy-1 ,1′-binaphthyl

Seung Wan Kang, Dong Hyun Ko, Kyoung Hoon Kim, Deok Chan Ha

College of Science

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

(Equation presented) A new N-triflated amino alcohol-titanium catalyst was designed for the asymmetric ethylation of aldehydes. This binaphthyl-based sulfonamido alcohol ligand shows uniformly high yield and enantioselectivity in the diethylzinc additions of aromatic, aliphatic, and unsaturated aldehydes.

Original language	English
Pages (from-to)	4517-4519
Number of pages	3
Journal	Organic Letters
Volume	5
Issue number	23
DOIs	https://doi.org/10.1021/ol0358511
Publication status	Published - 2003 Nov 13

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol0358511

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title = "Highly Enantioselective Additions of Diethylzinc to Aldehydes Using 2-Triflamido-methyl-2′-hydroxy-1 ,1′-binaphthyl",

abstract = "(Equation presented) A new N-triflated amino alcohol-titanium catalyst was designed for the asymmetric ethylation of aldehydes. This binaphthyl-based sulfonamido alcohol ligand shows uniformly high yield and enantioselectivity in the diethylzinc additions of aromatic, aliphatic, and unsaturated aldehydes.",

author = "Kang, {Seung Wan} and Ko, {Dong Hyun} and Kim, {Kyoung Hoon} and Ha, {Deok Chan}",

year = "2003",

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AU - Kang, Seung Wan

AU - Ko, Dong Hyun

AU - Kim, Kyoung Hoon

AU - Ha, Deok Chan

PY - 2003/11/13

Y1 - 2003/11/13

N2 - (Equation presented) A new N-triflated amino alcohol-titanium catalyst was designed for the asymmetric ethylation of aldehydes. This binaphthyl-based sulfonamido alcohol ligand shows uniformly high yield and enantioselectivity in the diethylzinc additions of aromatic, aliphatic, and unsaturated aldehydes.

AB - (Equation presented) A new N-triflated amino alcohol-titanium catalyst was designed for the asymmetric ethylation of aldehydes. This binaphthyl-based sulfonamido alcohol ligand shows uniformly high yield and enantioselectivity in the diethylzinc additions of aromatic, aliphatic, and unsaturated aldehydes.

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U2 - 10.1021/ol0358511

DO - 10.1021/ol0358511

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SP - 4517

EP - 4519

JO - Organic Letters

JF - Organic Letters

IS - 23

ER -

Highly Enantioselective Additions of Diethylzinc to Aldehydes Using 2-Triflamido-methyl-2′-hydroxy-1 ,1′-binaphthyl

Abstract

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