Highly selective in vivo imaging of endogenous/exogenous phosphate ion over ATP and PPi

Jun Feng Zhang; Lin E. Guo; Tie Nan Zang; Yu Lian Duan; Xin Yi Liu; Zhigang Yang; Peter Verwilst; Kaijun Luo; Guang Ke Wang; Jun Feng Kou; Ying Zhou; Jong Seung Kim

doi:10.1002/asia.201500091

Highly selective in vivo imaging of endogenous/exogenous phosphate ion over ATP and PP_i

Jun Feng Zhang^*
, Lin E. Guo
, Tie Nan Zang
, Yu Lian Duan
, Xin Yi Liu
, Zhigang Yang
, Peter Verwilst
, Kaijun Luo
, Guang Ke Wang
, Jun Feng Kou
, Ying Zhou
, Jong Seung Kim

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

A chemodosimeter was designed to function as a highly selective phosphate ion (P_i) sensor, showing a 91-fold ratiometric fluorescence enhancement. The probe successfully visualized exogenous and endogenous apyrase-catalyzed P_i generation and was the first probe able to trace the generation and enrichment of P_i through hemichannel closure in Sf9 cells.

Original language	English
Pages (from-to)	1165-1169
Number of pages	5
Journal	Chemistry - An Asian Journal
Volume	10
Issue number	5
DOIs	https://doi.org/10.1002/asia.201500091
Publication status	Published - 2015 May 1

Bibliographical note

Publisher Copyright:
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

1 8-naphthalene imide
fluorescent probes
in vivo imaging
inorganic phosphate
sensors

ASJC Scopus subject areas

General Chemistry
Biochemistry
Organic Chemistry

Access to Document

10.1002/asia.201500091

Cite this

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title = "Highly selective in vivo imaging of endogenous/exogenous phosphate ion over ATP and PPi",

abstract = "A chemodosimeter was designed to function as a highly selective phosphate ion (Pi) sensor, showing a 91-fold ratiometric fluorescence enhancement. The probe successfully visualized exogenous and endogenous apyrase-catalyzed Pi generation and was the first probe able to trace the generation and enrichment of Pi through hemichannel closure in Sf9 cells.",

keywords = "1 8-naphthalene imide, fluorescent probes, in vivo imaging, inorganic phosphate, sensors",

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AU - Zhang, Jun Feng

AU - Guo, Lin E.

AU - Zang, Tie Nan

AU - Duan, Yu Lian

AU - Liu, Xin Yi

AU - Yang, Zhigang

AU - Verwilst, Peter

AU - Luo, Kaijun

AU - Wang, Guang Ke

AU - Kou, Jun Feng

AU - Zhou, Ying

AU - Kim, Jong Seung

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KW - 1 8-naphthalene imide

KW - fluorescent probes

KW - in vivo imaging

KW - inorganic phosphate

KW - sensors

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