Highly Sensitive and Selective Fluorescent Probe for Ascorbic Acid with a Broad Detection Range through Dual-Quenching and Bimodal Action of Nitronyl-Nitroxide

Haerim Nam; Ji Eon Kwon; Min Woo Choi; Jangwon Seo; Seunghoon Shin; Sehoon Kim; Soo Young Park

doi:10.1021/acssensors.5b00230

Highly Sensitive and Selective Fluorescent Probe for Ascorbic Acid with a Broad Detection Range through Dual-Quenching and Bimodal Action of Nitronyl-Nitroxide

Haerim Nam, Ji Eon Kwon, Min Woo Choi, Jangwon Seo, Seunghoon Shin, Sehoon Kim, Soo Young Park

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

A novel nitronyl-nitroxide derivative for highly sensitive and selective detection of ascorbic acid (AA) is reported. The probe showed 260-fold fluorescence turn-on and diminished electron spin resonance (ESR) signal upon AA addition. The probe could detect AA over a broad concentration range from 1 μM to 2 mM and excellent selectivity over various antioxidants and acids through a combination of fluorescence and ESR responses, which originated from the dual-reactiveness of dual-quenching group nitronyl-nitroxide. We successfully demonstrated practical application potential of the probe by preparing nanoparticles and sensor papers and determining AA concentration in real samples including vitamin drinks and orange juices.

Original language	English
Pages (from-to)	392-398
Number of pages	7
Journal	ACS Sensors
Volume	1
Issue number	4
DOIs	https://doi.org/10.1021/acssensors.5b00230
Publication status	Published - 2016 Apr 22

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) through a grant funded by the Korean Government (MSIP; no. 2009-0081671 [RIAM0417-20150013]) and by the Air Force Office of Scientific Research (AFOSR: Grant No. FA23861214008).

Publisher Copyright:
© 2016 American Chemical Society.

Keywords

ascorbic acid
electron spin resonance
fluorescence
nitronyl-nitroxide
sensor

ASJC Scopus subject areas

Bioengineering
Instrumentation
Process Chemistry and Technology
Fluid Flow and Transfer Processes

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10.1021/acssensors.5b00230

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title = "Highly Sensitive and Selective Fluorescent Probe for Ascorbic Acid with a Broad Detection Range through Dual-Quenching and Bimodal Action of Nitronyl-Nitroxide",

abstract = "A novel nitronyl-nitroxide derivative for highly sensitive and selective detection of ascorbic acid (AA) is reported. The probe showed 260-fold fluorescence turn-on and diminished electron spin resonance (ESR) signal upon AA addition. The probe could detect AA over a broad concentration range from 1 μM to 2 mM and excellent selectivity over various antioxidants and acids through a combination of fluorescence and ESR responses, which originated from the dual-reactiveness of dual-quenching group nitronyl-nitroxide. We successfully demonstrated practical application potential of the probe by preparing nanoparticles and sensor papers and determining AA concentration in real samples including vitamin drinks and orange juices.",

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author = "Haerim Nam and Kwon, {Ji Eon} and Choi, {Min Woo} and Jangwon Seo and Seunghoon Shin and Sehoon Kim and Park, {Soo Young}",

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T1 - Highly Sensitive and Selective Fluorescent Probe for Ascorbic Acid with a Broad Detection Range through Dual-Quenching and Bimodal Action of Nitronyl-Nitroxide

AU - Nam, Haerim

AU - Kwon, Ji Eon

AU - Choi, Min Woo

AU - Seo, Jangwon

AU - Shin, Seunghoon

AU - Kim, Sehoon

AU - Park, Soo Young

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) through a grant funded by the Korean Government (MSIP; no. 2009-0081671 [RIAM0417-20150013]) and by the Air Force Office of Scientific Research (AFOSR: Grant No. FA23861214008). Publisher Copyright: © 2016 American Chemical Society.

PY - 2016/4/22

Y1 - 2016/4/22

N2 - A novel nitronyl-nitroxide derivative for highly sensitive and selective detection of ascorbic acid (AA) is reported. The probe showed 260-fold fluorescence turn-on and diminished electron spin resonance (ESR) signal upon AA addition. The probe could detect AA over a broad concentration range from 1 μM to 2 mM and excellent selectivity over various antioxidants and acids through a combination of fluorescence and ESR responses, which originated from the dual-reactiveness of dual-quenching group nitronyl-nitroxide. We successfully demonstrated practical application potential of the probe by preparing nanoparticles and sensor papers and determining AA concentration in real samples including vitamin drinks and orange juices.

AB - A novel nitronyl-nitroxide derivative for highly sensitive and selective detection of ascorbic acid (AA) is reported. The probe showed 260-fold fluorescence turn-on and diminished electron spin resonance (ESR) signal upon AA addition. The probe could detect AA over a broad concentration range from 1 μM to 2 mM and excellent selectivity over various antioxidants and acids through a combination of fluorescence and ESR responses, which originated from the dual-reactiveness of dual-quenching group nitronyl-nitroxide. We successfully demonstrated practical application potential of the probe by preparing nanoparticles and sensor papers and determining AA concentration in real samples including vitamin drinks and orange juices.

KW - ascorbic acid

KW - electron spin resonance

KW - fluorescence

KW - nitronyl-nitroxide

KW - sensor

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SP - 392

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JO - ACS Sensors

JF - ACS Sensors

IS - 4

ER -

Highly Sensitive and Selective Fluorescent Probe for Ascorbic Acid with a Broad Detection Range through Dual-Quenching and Bimodal Action of Nitronyl-Nitroxide

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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