Herein, we demonstrate a sulfur-doped reduced graphene oxide (SrGO) product fabricated using an eco-friendly biomass precursor “lenthionine” through a high temperature doping process. The product is used for making a highly sensitive electrochemical sensor for detection of 8-hydroxy-2′-deoxyguanosine (8-OHdG) molecule, which is an important biomarker for oxidative stress, cardiovascular diseases, and cancers. The sulfur-doping amount was regulated and a maximum sulfur content of 2.28 atom% was achieved through controlling the precursor amount. Homogenous presence of large number of sulfur atoms in SrGO in the form of thiophenic ([sbnd]C[sbnd]S[sbnd]C[sbnd]) bond produced robust sensitivity (∼1 nM), very wide detection window (20–0.002 μM), good selectivity, high stability and reproducibility, and excellent recoveries for the detection of 8-OHdG biomarker in optimized experimental conditions. The excellent electrochemical sensitivity of SrGO sensor is attributed to the strong electron-donating ability of sulfur that facilitates the electron transfer to the biomolecules in the electrochemical reactions. Thus, the proposed method endorses an excellent platform for the electrochemical detection of 8-OHdG with great ease and reliability.
Bibliographical noteFunding Information:
This work was supported by Fundamental R&D Program for Core Technology of Materials and the Industrial Strategic Technology Development Program funded by the Ministry of Trade, Industry and Energy, Republic of Korea . This work was also partially supported by Nano·Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning, Republic of Korea and partially by Korea Institute of Science and Technology. SAZ is grateful for research fund in 2016 by Kwangwoon University .
© 2016 Elsevier B.V.
- Electrochemical sensor
- Sulfur doping
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Condensed Matter Physics
- Surfaces, Coatings and Films
- Metals and Alloys
- Electrical and Electronic Engineering
- Materials Chemistry