Highly sensitive electrochemical sensor based on environmentally friendly biomass-derived sulfur-doped graphene for cancer biomarker detection

Faisal Shahzad; Shabi Abbas Zaidi; Chong Min Koo

doi:10.1016/j.snb.2016.10.144

Highly sensitive electrochemical sensor based on environmentally friendly biomass-derived sulfur-doped graphene for cancer biomarker detection

Faisal Shahzad, Shabi Abbas Zaidi, Chong Min Koo

Research output: Contribution to journal › Article › peer-review

85 Citations (Scopus)

Abstract

Herein, we demonstrate a sulfur-doped reduced graphene oxide (SrGO) product fabricated using an eco-friendly biomass precursor “lenthionine” through a high temperature doping process. The product is used for making a highly sensitive electrochemical sensor for detection of 8-hydroxy-2′-deoxyguanosine (8-OHdG) molecule, which is an important biomarker for oxidative stress, cardiovascular diseases, and cancers. The sulfur-doping amount was regulated and a maximum sulfur content of 2.28 atom% was achieved through controlling the precursor amount. Homogenous presence of large number of sulfur atoms in SrGO in the form of thiophenic ([sbnd]C[sbnd]S[sbnd]C[sbnd]) bond produced robust sensitivity (∼1 nM), very wide detection window (20–0.002 μM), good selectivity, high stability and reproducibility, and excellent recoveries for the detection of 8-OHdG biomarker in optimized experimental conditions. The excellent electrochemical sensitivity of SrGO sensor is attributed to the strong electron-donating ability of sulfur that facilitates the electron transfer to the biomolecules in the electrochemical reactions. Thus, the proposed method endorses an excellent platform for the electrochemical detection of 8-OHdG with great ease and reliability.

Original language	English
Pages (from-to)	716-724
Number of pages	9
Journal	Sensors and Actuators, B: Chemical
Volume	241
DOIs	https://doi.org/10.1016/j.snb.2016.10.144
Publication status	Published - 2017 Mar 31
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by Fundamental R&D Program for Core Technology of Materials and the Industrial Strategic Technology Development Program funded by the Ministry of Trade, Industry and Energy, Republic of Korea . This work was also partially supported by Nano·Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning, Republic of Korea and partially by Korea Institute of Science and Technology. SAZ is grateful for research fund in 2016 by Kwangwoon University .

Publisher Copyright:
© 2016 Elsevier B.V.

Keywords

8-hydroxy-2′-deoxyguanosine
Biomass
Electrochemical sensor
Graphene
Sulfur doping

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.snb.2016.10.144

Cite this

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title = "Highly sensitive electrochemical sensor based on environmentally friendly biomass-derived sulfur-doped graphene for cancer biomarker detection",

abstract = "Herein, we demonstrate a sulfur-doped reduced graphene oxide (SrGO) product fabricated using an eco-friendly biomass precursor “lenthionine” through a high temperature doping process. The product is used for making a highly sensitive electrochemical sensor for detection of 8-hydroxy-2′-deoxyguanosine (8-OHdG) molecule, which is an important biomarker for oxidative stress, cardiovascular diseases, and cancers. The sulfur-doping amount was regulated and a maximum sulfur content of 2.28 atom% was achieved through controlling the precursor amount. Homogenous presence of large number of sulfur atoms in SrGO in the form of thiophenic ([sbnd]C[sbnd]S[sbnd]C[sbnd]) bond produced robust sensitivity (∼1 nM), very wide detection window (20–0.002 μM), good selectivity, high stability and reproducibility, and excellent recoveries for the detection of 8-OHdG biomarker in optimized experimental conditions. The excellent electrochemical sensitivity of SrGO sensor is attributed to the strong electron-donating ability of sulfur that facilitates the electron transfer to the biomolecules in the electrochemical reactions. Thus, the proposed method endorses an excellent platform for the electrochemical detection of 8-OHdG with great ease and reliability.",

keywords = "8-hydroxy-2′-deoxyguanosine, Biomass, Electrochemical sensor, Graphene, Sulfur doping",

author = "Faisal Shahzad and Zaidi, {Shabi Abbas} and Koo, {Chong Min}",

note = "Funding Information: This work was supported by Fundamental R&D Program for Core Technology of Materials and the Industrial Strategic Technology Development Program funded by the Ministry of Trade, Industry and Energy, Republic of Korea . This work was also partially supported by Nano·Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning, Republic of Korea and partially by Korea Institute of Science and Technology. SAZ is grateful for research fund in 2016 by Kwangwoon University . Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

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AU - Shahzad, Faisal

AU - Zaidi, Shabi Abbas

AU - Koo, Chong Min

N1 - Funding Information: This work was supported by Fundamental R&D Program for Core Technology of Materials and the Industrial Strategic Technology Development Program funded by the Ministry of Trade, Industry and Energy, Republic of Korea . This work was also partially supported by Nano·Material Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning, Republic of Korea and partially by Korea Institute of Science and Technology. SAZ is grateful for research fund in 2016 by Kwangwoon University . Publisher Copyright: © 2016 Elsevier B.V.

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N2 - Herein, we demonstrate a sulfur-doped reduced graphene oxide (SrGO) product fabricated using an eco-friendly biomass precursor “lenthionine” through a high temperature doping process. The product is used for making a highly sensitive electrochemical sensor for detection of 8-hydroxy-2′-deoxyguanosine (8-OHdG) molecule, which is an important biomarker for oxidative stress, cardiovascular diseases, and cancers. The sulfur-doping amount was regulated and a maximum sulfur content of 2.28 atom% was achieved through controlling the precursor amount. Homogenous presence of large number of sulfur atoms in SrGO in the form of thiophenic ([sbnd]C[sbnd]S[sbnd]C[sbnd]) bond produced robust sensitivity (∼1 nM), very wide detection window (20–0.002 μM), good selectivity, high stability and reproducibility, and excellent recoveries for the detection of 8-OHdG biomarker in optimized experimental conditions. The excellent electrochemical sensitivity of SrGO sensor is attributed to the strong electron-donating ability of sulfur that facilitates the electron transfer to the biomolecules in the electrochemical reactions. Thus, the proposed method endorses an excellent platform for the electrochemical detection of 8-OHdG with great ease and reliability.

AB - Herein, we demonstrate a sulfur-doped reduced graphene oxide (SrGO) product fabricated using an eco-friendly biomass precursor “lenthionine” through a high temperature doping process. The product is used for making a highly sensitive electrochemical sensor for detection of 8-hydroxy-2′-deoxyguanosine (8-OHdG) molecule, which is an important biomarker for oxidative stress, cardiovascular diseases, and cancers. The sulfur-doping amount was regulated and a maximum sulfur content of 2.28 atom% was achieved through controlling the precursor amount. Homogenous presence of large number of sulfur atoms in SrGO in the form of thiophenic ([sbnd]C[sbnd]S[sbnd]C[sbnd]) bond produced robust sensitivity (∼1 nM), very wide detection window (20–0.002 μM), good selectivity, high stability and reproducibility, and excellent recoveries for the detection of 8-OHdG biomarker in optimized experimental conditions. The excellent electrochemical sensitivity of SrGO sensor is attributed to the strong electron-donating ability of sulfur that facilitates the electron transfer to the biomolecules in the electrochemical reactions. Thus, the proposed method endorses an excellent platform for the electrochemical detection of 8-OHdG with great ease and reliability.

KW - 8-hydroxy-2′-deoxyguanosine

KW - Biomass

KW - Electrochemical sensor

KW - Graphene

KW - Sulfur doping

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ER -

Highly sensitive electrochemical sensor based on environmentally friendly biomass-derived sulfur-doped graphene for cancer biomarker detection

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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