Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway

Yoonhee Bae; Dongwon Choi; Hyangshuk Rhim; Seongman Kang

doi:10.1016/j.febslet.2010.10.016

Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway

Yoonhee Bae, Dongwon Choi, Hyangshuk Rhim, Seongman Kang

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Hip2, a ubiquitin conjugating enzyme, is involved in the suppression of cell death. The present study revealed that Hip2 regulates the stability of the apoptotic and cell cycle regulator cyclin B1. Hip2 was found to interact with cyclin B1 to promote its degradation through the ubiquitin proteasome pathway. As a result, Hip2 significantly blocked cell death induced by the cyclin B1 protein, suggesting that Hip2 is involved in the regulation of cyclin B1-mediated cell death. Structured summary: MINT- 8045218, MINT- 8045231: Hip2 (uniprotkb: P61086) physically interacts (MI: 0915) with cyclin-B1 (uniprotkb: P14635) by pull down (MI: 0096).

Original language	English
Pages (from-to)	4505-4510
Number of pages	6
Journal	FEBS Letters
Volume	584
Issue number	22
DOIs	https://doi.org/10.1016/j.febslet.2010.10.016
Publication status	Published - 2010 Nov 19

Keywords

Apoptosis
Cyclin B1
Hip2
Ubiquitination

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/j.febslet.2010.10.016

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title = "Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway",

abstract = "Hip2, a ubiquitin conjugating enzyme, is involved in the suppression of cell death. The present study revealed that Hip2 regulates the stability of the apoptotic and cell cycle regulator cyclin B1. Hip2 was found to interact with cyclin B1 to promote its degradation through the ubiquitin proteasome pathway. As a result, Hip2 significantly blocked cell death induced by the cyclin B1 protein, suggesting that Hip2 is involved in the regulation of cyclin B1-mediated cell death. Structured summary: MINT- 8045218, MINT- 8045231: Hip2 (uniprotkb: P61086) physically interacts (MI: 0915) with cyclin-B1 (uniprotkb: P14635) by pull down (MI: 0096).",

keywords = "Apoptosis, Cyclin B1, Hip2, Ubiquitination",

author = "Yoonhee Bae and Dongwon Choi and Hyangshuk Rhim and Seongman Kang",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government ( 200601742 ) and a Grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs , the Republic of Korea ( A084358 ). Also, we are thank Ok Jeong Noh and Juno Jang for helpful material and method. ",

year = "2010",

month = nov,

day = "19",

doi = "10.1016/j.febslet.2010.10.016",

language = "English",

volume = "584",

pages = "4505--4510",

journal = "FEBS Letters",

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T1 - Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway

AU - Bae, Yoonhee

AU - Choi, Dongwon

AU - Rhim, Hyangshuk

AU - Kang, Seongman

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea government ( 200601742 ) and a Grant from the Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs , the Republic of Korea ( A084358 ). Also, we are thank Ok Jeong Noh and Juno Jang for helpful material and method.

PY - 2010/11/19

Y1 - 2010/11/19

N2 - Hip2, a ubiquitin conjugating enzyme, is involved in the suppression of cell death. The present study revealed that Hip2 regulates the stability of the apoptotic and cell cycle regulator cyclin B1. Hip2 was found to interact with cyclin B1 to promote its degradation through the ubiquitin proteasome pathway. As a result, Hip2 significantly blocked cell death induced by the cyclin B1 protein, suggesting that Hip2 is involved in the regulation of cyclin B1-mediated cell death. Structured summary: MINT- 8045218, MINT- 8045231: Hip2 (uniprotkb: P61086) physically interacts (MI: 0915) with cyclin-B1 (uniprotkb: P14635) by pull down (MI: 0096).

AB - Hip2, a ubiquitin conjugating enzyme, is involved in the suppression of cell death. The present study revealed that Hip2 regulates the stability of the apoptotic and cell cycle regulator cyclin B1. Hip2 was found to interact with cyclin B1 to promote its degradation through the ubiquitin proteasome pathway. As a result, Hip2 significantly blocked cell death induced by the cyclin B1 protein, suggesting that Hip2 is involved in the regulation of cyclin B1-mediated cell death. Structured summary: MINT- 8045218, MINT- 8045231: Hip2 (uniprotkb: P61086) physically interacts (MI: 0915) with cyclin-B1 (uniprotkb: P14635) by pull down (MI: 0096).

KW - Apoptosis

KW - Cyclin B1

KW - Hip2

KW - Ubiquitination

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DO - 10.1016/j.febslet.2010.10.016

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SN - 0014-5793

VL - 584

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EP - 4510

JO - FEBS Letters

JF - FEBS Letters

IS - 22

ER -

Hip2 interacts with cyclin B1 and promotes its degradation through the ubiquitin proteasome pathway

Abstract

Keywords

ASJC Scopus subject areas

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