Hippocampal volume and shape in pure subcortical vascular dementia

Geon Ha Kim, Jae Hong Lee, Sang Won Seo, Jeong Hun Kim, Joon Kyung Seong, Byoung Seok Ye, Hanna Cho, Young Noh, Hee Jin Kim, Cindy W. Yoon, Seung Jun Oh, Jae Seung Kim, Yearn Seong Choe, Kyung Han Lee, Sung Tae Kim, Jung Won Hwang, Jee Hyang Jeong, Duk L. Na

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


The purposes of the present study were to explore whether hippocampal atrophy exists in pure subcortical vascular dementia (SVaD) as defined by negative 11C-Pittsburg compound-B (PiB-) positron emission tomography and to compare hippocampal volume and shape between PiB- SVaD and PiB positive (PiB+) Alzheimer's disease (AD) dementia. Hippocampal volume and shape were compared among 40 patients with PiB- SVaD, 34 with PiB+ AD, and 21 elderly with normal cognitive function (NC). The normalized hippocampal volume of PiB- SVaD was significantly smaller than NC but larger than that of PiB+ AD (NC > PiB- SVaD > PiB+ AD). Both PiB- SVaD and PiB+ AD patients had deflated shape changes in the cornus ammonis (CA) 1 and subiculum compared with NC. However, direct comparison between PiB- SVaD and PiB+ AD demonstrated more inward deformity in the subiculum of the left hippocampus in PiB+ AD. PiB- SVaD patients did have smaller hippocampal volumes and inward shape change on CA 1 and subiculum compared with NC, suggesting that cumulative ischemia without amyloid pathology could lead to hippocampal atrophy and shape changes.

Original languageEnglish
Pages (from-to)485-491
Number of pages7
JournalNeurobiology of Aging
Issue number1
Publication statusPublished - 2015 Jan 1

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.


  • Alzheimer's disease
  • Hippocampus
  • PiB-PET
  • Vascular dementia

ASJC Scopus subject areas

  • General Neuroscience
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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