Histopathologic differences in the photoaging process in facial versus arm skin

J. Bhawan, Chil Hwan Oh, R. Lew, K. S. Nehal, R. R. Labadie, A. Tsay, B. A. Gilchrest

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


We used clinical criteria to study skin biopsy specimens with mild to moderate photoaging taken from the face and dorsal forearms of 74 Caucasian volunteers between the ages of 30 and 50. Facial skin had a greater number of granular cell layers, a higher degree of keratinocytic atypia, and more often showed a compact stratum corneum than arm skin. Furthermore, the dermis of facial skin had a more extensive perivascular and perifollicular lymphocytic infiltrate, more perifollicular fibrosis, a greater number of mast cells and melanophages, and thinner vascular walls than forearm skin. This study demonstrated that the photoaging process is different for face and arm skin. Appreciation of these differences should permit more refined studies of photoaging and the development of more efficient therapies.

Original languageEnglish
Pages (from-to)224-230
Number of pages7
JournalAmerican Journal of Dermatopathology
Issue number3
Publication statusPublished - 1992 Jan 1
Externally publishedYes


  • Arm
  • Face
  • Histology
  • Photoaging
  • Skin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology


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