Hollow silica nanocontainers as drug delivery vehicles

Jaemoon Yang; Jaewon Lee; Jinyoung Kang; Kwangyeol Lee; Jin Suck Suh; Ho Geun Yoon; Yong Mip Huh; Seungjoo Haam

doi:10.1021/la701688t

Hollow silica nanocontainers as drug delivery vehicles

Jaemoon Yang
, Jaewon Lee
, Jinyoung Kang
, Kwangyeol Lee
, Jin Suck Suh
, Ho Geun Yoon
, Yong Mip Huh
, Seungjoo Haam^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

251 Citations (Scopus)

Abstract

Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe₃O₄ nanocrystals, as templates. The core cavity was obtained by removal of Fe₃O₄ phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.

Original language	English
Pages (from-to)	3417-3421
Number of pages	5
Journal	Langmuir
Volume	24
Issue number	7
DOIs	https://doi.org/10.1021/la701688t
Publication status	Published - 2008 Apr 1

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

Access to Document

10.1021/la701688t

Cite this

@article{6fbbc21ff77e4afb9796ce95569e3bb9,

title = "Hollow silica nanocontainers as drug delivery vehicles",

abstract = "Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe3O4 nanocrystals, as templates. The core cavity was obtained by removal of Fe3O4 phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.",

author = "Jaemoon Yang and Jaewon Lee and Jinyoung Kang and Kwangyeol Lee and Suh, \{Jin Suck\} and Yoon, \{Ho Geun\} and Huh, \{Yong Mip\} and Seungjoo Haam",

year = "2008",

month = apr,

day = "1",

doi = "10.1021/la701688t",

language = "English",

volume = "24",

pages = "3417--3421",

journal = "Langmuir",

issn = "0743-7463",

publisher = "American Chemical Society",

number = "7",

}

TY - JOUR

T1 - Hollow silica nanocontainers as drug delivery vehicles

AU - Yang, Jaemoon

AU - Lee, Jaewon

AU - Kang, Jinyoung

AU - Lee, Kwangyeol

AU - Suh, Jin Suck

AU - Yoon, Ho Geun

AU - Huh, Yong Mip

AU - Haam, Seungjoo

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe3O4 nanocrystals, as templates. The core cavity was obtained by removal of Fe3O4 phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.

AB - Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number of Fe3O4 nanocrystals, as templates. The core cavity was obtained by removal of Fe3O4 phase with hydrochloric acid and subsequent calcination at a high temperature. HSNPs were modified by amine in order to introduce positive surface charge and further PEGylated for increased solubility in aqueous medium. Doxorubicin as a model drug was loaded into the HSNPs, and notable sustained drug release from HSNPs was demonstrated.

UR - https://www.scopus.com/pages/publications/42249094044

U2 - 10.1021/la701688t

DO - 10.1021/la701688t

M3 - Article

C2 - 18324841

AN - SCOPUS:42249094044

SN - 0743-7463

VL - 24

SP - 3417

EP - 3421

JO - Langmuir

JF - Langmuir

IS - 7

ER -

Hollow silica nanocontainers as drug delivery vehicles

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this