TY - JOUR
T1 - Homochiral porous nanosheets for enantiomer sieving
AU - Sun, Bo
AU - Kim, Yongju
AU - Wang, Yanqiu
AU - Wang, Huaxin
AU - Kim, Jehan
AU - Liu, Xin
AU - Lee, Myongsoo
N1 - Funding Information:
This work was supported by the National Natural Science Foundation of China (grants 21634005, 51473062 and 21574055) and Jilin University Funding (JLUSTIRT).
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Protein pores are highly specific in binding to chiral substrates and in catalysing stereospecific reactions, because their active pockets are asymmetric and stereoselective 1,2 . Chiral binding materials from molecular-level pores with high specificity have not been achieved because of problems with pore deformation and blocking 3 . A promising solution is the self-assembly of single sheets where all pores are exposed to the environment, for example as metal-organic frameworks 4, polymers 5,6 or non-covalent aromatic networks 7-10, but, typically, the pores are distant from the internal cavities with chirality. Here, we report the synthesis of homochiral porous nanosheets achieved by the 2D self-assembly of non-chiral macrocycles, with open/closed pore switching. Pore chirality is spontaneously induced by a twisted stack of dimeric macrocycles. The porous 2D structures can serve as enantiomer sieving membranes that exclusively capture a single enantiomer in a racemic mixture solution, with uptake capacity greater than 96%. Moreover, the entrapped guests inside the pores can be pumped out by pore closing triggered by external stimuli. This strategy could provide new opportunities for controlled molecule release, as well as for artificial cells.
AB - Protein pores are highly specific in binding to chiral substrates and in catalysing stereospecific reactions, because their active pockets are asymmetric and stereoselective 1,2 . Chiral binding materials from molecular-level pores with high specificity have not been achieved because of problems with pore deformation and blocking 3 . A promising solution is the self-assembly of single sheets where all pores are exposed to the environment, for example as metal-organic frameworks 4, polymers 5,6 or non-covalent aromatic networks 7-10, but, typically, the pores are distant from the internal cavities with chirality. Here, we report the synthesis of homochiral porous nanosheets achieved by the 2D self-assembly of non-chiral macrocycles, with open/closed pore switching. Pore chirality is spontaneously induced by a twisted stack of dimeric macrocycles. The porous 2D structures can serve as enantiomer sieving membranes that exclusively capture a single enantiomer in a racemic mixture solution, with uptake capacity greater than 96%. Moreover, the entrapped guests inside the pores can be pumped out by pore closing triggered by external stimuli. This strategy could provide new opportunities for controlled molecule release, as well as for artificial cells.
UR - http://www.scopus.com/inward/record.url?scp=85048324369&partnerID=8YFLogxK
U2 - 10.1038/s41563-018-0107-4
DO - 10.1038/s41563-018-0107-4
M3 - Article
C2 - 29891890
AN - SCOPUS:85048324369
SN - 1476-1122
VL - 17
SP - 599
EP - 6074
JO - Nature Materials
JF - Nature Materials
IS - 7
ER -