Homocysteine, folate and pregnancy outcomes

M. W. Kim; S. C. Hong; J. S. Choi; J. Y. Han; M. J. Oh; Hai Joong Kim; A. Nava-Ocampo; G. Koren

doi:10.3109/01443615.2012.693984

Homocysteine, folate and pregnancy outcomes

M. W. Kim
, S. C. Hong^*
, J. S. Choi
, J. Y. Han
, M. J. Oh
, Hai Joong Kim
, A. Nava-Ocampo
, G. Koren

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

The purpose of this study is to evaluate the relationship between maternal and/or cord blood folate/homocysteine concentrations and adverse pregnancy outcomes. The study population included a random sample of singleton pregnant women in whom we measured total homocysteine and folic acid in maternal or cord blood at deliveries. A total of 227 pregnant women were enrolled. The concentration of folate in maternal blood tended to be significantly lower in pre-term birth than in full-term delivery group (median (95% CI), 14.4 (3.673) vs 25 (7.3105.5) p <0.01). The total homocysteine in maternal and cord blood was significantly higher in the pre-eclampsia than in the normotensive group (7.9 (1.728.2) vs 5.9 (1.814.6) μmol/ml, p <0.05; and 5.8 (2.614.4) vs 4.2 (0.77.9) ng/ml, p <0.05, respectively). Lower maternal serum folate concentration is associated with pre-term delivery and higher maternal plasma homocysteine concentration with pre-eclampsia.

Original language	English
Pages (from-to)	520-524
Number of pages	5
Journal	Journal of Obstetrics and Gynaecology
Volume	32
Issue number	6
DOIs	https://doi.org/10.3109/01443615.2012.693984
Publication status	Published - 2012 Aug

Bibliographical note

Funding Information:
This study was supported by grant No. K1031741 from Korea University College of Medicine and a grant (A090858) of Health Care Research and Development Project, Ministry of Health and Welfare, Republic of Korea. No support was received from any pharmaceutical company.

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

Folate
Homocysteine
Pre-term delivery
Pregnancy outcomes

ASJC Scopus subject areas

Obstetrics and Gynaecology

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10.3109/01443615.2012.693984

Cite this

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title = "Homocysteine, folate and pregnancy outcomes",

abstract = "The purpose of this study is to evaluate the relationship between maternal and/or cord blood folate/homocysteine concentrations and adverse pregnancy outcomes. The study population included a random sample of singleton pregnant women in whom we measured total homocysteine and folic acid in maternal or cord blood at deliveries. A total of 227 pregnant women were enrolled. The concentration of folate in maternal blood tended to be significantly lower in pre-term birth than in full-term delivery group (median (95\% CI), 14.4 (3.673) vs 25 (7.3105.5) p <0.01). The total homocysteine in maternal and cord blood was significantly higher in the pre-eclampsia than in the normotensive group (7.9 (1.728.2) vs 5.9 (1.814.6) μmol/ml, p <0.05; and 5.8 (2.614.4) vs 4.2 (0.77.9) ng/ml, p <0.05, respectively). Lower maternal serum folate concentration is associated with pre-term delivery and higher maternal plasma homocysteine concentration with pre-eclampsia.",

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note = "Funding Information: This study was supported by grant No. K1031741 from Korea University College of Medicine and a grant (A090858) of Health Care Research and Development Project, Ministry of Health and Welfare, Republic of Korea. No support was received from any pharmaceutical company. Copyright: Copyright 2013 Elsevier B.V., All rights reserved.",

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doi = "10.3109/01443615.2012.693984",

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AU - Kim, Hai Joong

AU - Nava-Ocampo, A.

AU - Koren, G.

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N2 - The purpose of this study is to evaluate the relationship between maternal and/or cord blood folate/homocysteine concentrations and adverse pregnancy outcomes. The study population included a random sample of singleton pregnant women in whom we measured total homocysteine and folic acid in maternal or cord blood at deliveries. A total of 227 pregnant women were enrolled. The concentration of folate in maternal blood tended to be significantly lower in pre-term birth than in full-term delivery group (median (95% CI), 14.4 (3.673) vs 25 (7.3105.5) p <0.01). The total homocysteine in maternal and cord blood was significantly higher in the pre-eclampsia than in the normotensive group (7.9 (1.728.2) vs 5.9 (1.814.6) μmol/ml, p <0.05; and 5.8 (2.614.4) vs 4.2 (0.77.9) ng/ml, p <0.05, respectively). Lower maternal serum folate concentration is associated with pre-term delivery and higher maternal plasma homocysteine concentration with pre-eclampsia.

AB - The purpose of this study is to evaluate the relationship between maternal and/or cord blood folate/homocysteine concentrations and adverse pregnancy outcomes. The study population included a random sample of singleton pregnant women in whom we measured total homocysteine and folic acid in maternal or cord blood at deliveries. A total of 227 pregnant women were enrolled. The concentration of folate in maternal blood tended to be significantly lower in pre-term birth than in full-term delivery group (median (95% CI), 14.4 (3.673) vs 25 (7.3105.5) p <0.01). The total homocysteine in maternal and cord blood was significantly higher in the pre-eclampsia than in the normotensive group (7.9 (1.728.2) vs 5.9 (1.814.6) μmol/ml, p <0.05; and 5.8 (2.614.4) vs 4.2 (0.77.9) ng/ml, p <0.05, respectively). Lower maternal serum folate concentration is associated with pre-term delivery and higher maternal plasma homocysteine concentration with pre-eclampsia.

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Homocysteine, folate and pregnancy outcomes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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