Host switch during evolution of a genetically distinct hantavirus in the American shrew mole (Neurotrichus gibbsii)

Hae Ji Kang, Shannon N. Bennett, Laurie Dizney, Laarni Sumibcay, Satoru Arai, Luis A. Ruedas, Jin Won Song, Richard Yanagihara

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)

Abstract

A genetically distinct hantavirus, designated Oxbow virus (OXBV), was detected in tissues of an American shrew mole (Neurotrichus gibbsii), captured in Gresham, Oregon, in September 2003. Pairwise analysis of full-length S- and M- and partial L-segment nucleotide and amino acid sequences of OXBV indicated low sequence similarity with rodent-borne hantaviruses. Phylogenetic analyses using maximum-likelihood and Bayesian methods, and host-parasite evolutionary comparisons, showed that OXBV and Asama virus, a hantavirus recently identified from the Japanese shrew mole (Urotrichus talpoides), were related to soricine shrew-borne hantaviruses from North America and Eurasia, respectively, suggesting parallel evolution associated with cross-species transmission.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalVirology
Volume388
Issue number1
DOIs
Publication statusPublished - 2009 May 25
Externally publishedYes

Bibliographical note

Funding Information:
We thank Metro for providing access to Oxbow Regional Park. Permits for mammal trapping were obtained from the Oregon Department of Fish and Wildlife. This research was supported in part by U.S. Public Health Service grants R01AI075057 from the National Institute of Allergy and Infectious Diseases, and P20RR018727 (Centers of Biomedical Research Excellence) and G12RR003061 (Research Centers in Minority Institutions) from the National Center for Research Resources, National Institutes of Health, as well as grants from the American Society of Mammalogists, Sigma Delta Epsilon-Graduate Women in Science, Northwest Health Foundation and Forbes-Lea Fund at Portland State University.

Keywords

  • Hantavirus
  • Host switching
  • Phylogeny
  • Soricid
  • Talpid

ASJC Scopus subject areas

  • Virology

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