Abstract
A genetically distinct hantavirus, designated Oxbow virus (OXBV), was detected in tissues of an American shrew mole (Neurotrichus gibbsii), captured in Gresham, Oregon, in September 2003. Pairwise analysis of full-length S- and M- and partial L-segment nucleotide and amino acid sequences of OXBV indicated low sequence similarity with rodent-borne hantaviruses. Phylogenetic analyses using maximum-likelihood and Bayesian methods, and host-parasite evolutionary comparisons, showed that OXBV and Asama virus, a hantavirus recently identified from the Japanese shrew mole (Urotrichus talpoides), were related to soricine shrew-borne hantaviruses from North America and Eurasia, respectively, suggesting parallel evolution associated with cross-species transmission.
Original language | English |
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Pages (from-to) | 8-14 |
Number of pages | 7 |
Journal | Virology |
Volume | 388 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2009 May 25 |
Externally published | Yes |
Bibliographical note
Funding Information:We thank Metro for providing access to Oxbow Regional Park. Permits for mammal trapping were obtained from the Oregon Department of Fish and Wildlife. This research was supported in part by U.S. Public Health Service grants R01AI075057 from the National Institute of Allergy and Infectious Diseases, and P20RR018727 (Centers of Biomedical Research Excellence) and G12RR003061 (Research Centers in Minority Institutions) from the National Center for Research Resources, National Institutes of Health, as well as grants from the American Society of Mammalogists, Sigma Delta Epsilon-Graduate Women in Science, Northwest Health Foundation and Forbes-Lea Fund at Portland State University.
Keywords
- Hantavirus
- Host switching
- Phylogeny
- Soricid
- Talpid
ASJC Scopus subject areas
- Virology