Hot channels in airways: Pharmacology of the vanilloid receptor

Sun Wook Hwang, Uhtaek Oh

Research output: Contribution to journalReview articlepeer-review

53 Citations (Scopus)


Airway hyperresponsiveness of the tracheobronchial path is recognized as the critical feature of bronchial asthma. Sensory nerves in the airway are implicated strongly in this hyperresponsiveness. The vanilloid VR1 receptor, a cloned capsaicin receptor and a nociceptor-specific cation channel, is known to detect and transduce various harmful stimuli to electrical signals. Recent findings suggest that bradykinin can activate VR1 through generation of lipoxygenase products and that protein kinase C and phospholipase C mediate the sensitization of VR1 by many key inflammatory mediators. Such findings will lead to a better understanding of the enigmatic etiology of asthma.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalCurrent Opinion in Pharmacology
Issue number3
Publication statusPublished - 2002 Jun 1
Externally publishedYes

Bibliographical note

Funding Information:
The authors’ work is supported by National Creative Research Initiatives of the Ministry of Science and Technology of Korea and BK21 program.

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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