@article{94adbca0a1544c79bf14eb1fcf99592f,
title = "Human induced pluripotent stem cell line with cytochrome P450 enzyme polymorphism (CYP2C19*2/CYP3A5*3C) generated from lymphoblastoid cells",
abstract = "Cytochrome P450 (CYP) comprises a superfamily of monooxygenase responsible for the metabolism of xenobiotics and approximately 75% of drugs in use today. Thus, genetic polymorphisms in CYP genes contribute to interindividual differences in hepatic metabolism of drugs, affecting on individual drug efficacy and may cause adverse effects. Here, we generated a human induced pluripotent stem cell (hiPSC) line with pharmacologically important traits (CYP2C19*2/CYP3A5*3C), which are highly polymorphic in Asian from lymphoblastoid cells. This hiPSC line could be a valuable source for predicting individual drug responses in the drug screening process that uses hiPSC-derived somatic cells, including hepatocytes.",
author = "Jaehun Lee and Woo, {Dong Hun} and Park, {Han Jin} and Kijung Park and Ko, {Duck Sung} and Kim, {Jong Hoon}",
note = "Funding Information: We would like to thank Bom-Yi Lee and So-Yeon Park (Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center) for technical support in karyotype analysis. This study was provided with bioresources from National Biobank of Korea, the Centers for Disease Control and Prevention, Republic of Korea. This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (No. 2017M3A9B4042581 ). Funding Information: We would like to thank Bom-Yi Lee and So-Yeon Park (Laboratory of Medical Genetics, Cheil General Hospital and Women's Healthcare Center) for technical support in karyotype analysis. This study was provided with bioresources from National Biobank of Korea, the Centers for Disease Control and Prevention, Republic of Korea. This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MEST) (No. 2017M3A9B4042581). Publisher Copyright: {\textcopyright} 2017",
year = "2018",
month = mar,
doi = "10.1016/j.scr.2017.12.014",
language = "English",
volume = "27",
pages = "34--37",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",
}