Humidity-Tolerant Single-Stranded DNA-Functionalized Graphene Probe for Medical Applications of Exhaled Breath Analysis

Youngmo Jung; Hi Gyu Moon; Chaehyun Lim; Keunsu Choi; Hyun Seok Song; Sukang Bae; Soo Min Kim; Minah Seo; Taikjin Lee; Seok Lee; Hyung Ho Park; Seong Chan Jun; Chong Yun Kang; Chulki Kim

doi:10.1002/adfm.201700068

Humidity-Tolerant Single-Stranded DNA-Functionalized Graphene Probe for Medical Applications of Exhaled Breath Analysis

Youngmo Jung, Hi Gyu Moon, Chaehyun Lim, Keunsu Choi, Hyun Seok Song, Sukang Bae, Soo Min Kim, Minah Seo, Taikjin Lee, Seok Lee, Hyung Ho Park, Seong Chan Jun, Chong Yun Kang, Chulki Kim

KU-KIST Graduate School of Converging Science and Technology

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Highly sensitive and selective chemiresistive sensors based on graphene functionalized by metals and metal oxides have attracted considerable attention in the fields of environmental monitoring and medical assessment because of their ultrasensitive gas detecting performance and cost-effective fabrication. However, their operation, in terms of detection limit and reliability, is limited in traditional applications because of ambient humidity. Here, the enhanced sensitivity and selectivity of single-stranded DNA-functionalized graphene (ssDNA-FG) sensors to NH₃ and H₂S vapors at high humidity are demonstrated and their sensing mechanism is suggested. It is found that depositing a layer of ssDNA molecules leads to effective modulation of carrier density in graphene, as a negative-potential gating agent and the formation of an additional ion conduction path for proton hopping in the layer of hydronium ions (H₃O⁺) at high humidity (>80%). Considering that selectively responsive chemical vapors are biomarkers associated with human diseases, the obtained results strongly suggest that ssDNA-FG sensors can be the key to developing a high-performance exhaled breath analyzer for diagnosing halitosis and kidney disorder.

Original language	English
Article number	1700068
Journal	Advanced Functional Materials
Volume	27
Issue number	26
DOIs	https://doi.org/10.1002/adfm.201700068
Publication status	Published - 2017 Jul 12

Bibliographical note

Funding Information:
Y.J. and H.G.M. contributed equally to this work. This work was partly supported by the KIST Institutional Program (Project No. 2E27270), the Global Top Project funded by the Korean Ministry of Environment (GT-11-F-02-002-1), Nano-Material Technology Development Program (2012M3A7B4049804), the Industrial Technology Innovation Program (10054548) funded by the Ministry of Trade, Industry, & Energy (MI, Korea), and an Institute for Information & Communications Technology Promotion (IITP) grant funded by the Korea government (MSIP) (No. R0126-16-1050, Olfactory Bio Data based Emotion Enhancement Interactive Content Technology Development).

Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

chemiresistive graphene sensors
exhaled breath analyzers
halitosis
kidney disorders
single-stranded (ss) DNA-functionalization

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
General Chemistry
General Materials Science
Electrochemistry
Biomaterials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adfm.201700068

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Jung, Y., Moon, H. G., Lim, C., Choi, K., Song, H. S., Bae, S., Kim, S. M., Seo, M., Lee, T., Lee, S., Park, H. H., Jun, S. C., Kang, C. Y., & Kim, C. (2017). Humidity-Tolerant Single-Stranded DNA-Functionalized Graphene Probe for Medical Applications of Exhaled Breath Analysis. Advanced Functional Materials, 27(26), Article 1700068. https://doi.org/10.1002/adfm.201700068

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abstract = "Highly sensitive and selective chemiresistive sensors based on graphene functionalized by metals and metal oxides have attracted considerable attention in the fields of environmental monitoring and medical assessment because of their ultrasensitive gas detecting performance and cost-effective fabrication. However, their operation, in terms of detection limit and reliability, is limited in traditional applications because of ambient humidity. Here, the enhanced sensitivity and selectivity of single-stranded DNA-functionalized graphene (ssDNA-FG) sensors to NH3 and H2S vapors at high humidity are demonstrated and their sensing mechanism is suggested. It is found that depositing a layer of ssDNA molecules leads to effective modulation of carrier density in graphene, as a negative-potential gating agent and the formation of an additional ion conduction path for proton hopping in the layer of hydronium ions (H3O+) at high humidity (>80%). Considering that selectively responsive chemical vapors are biomarkers associated with human diseases, the obtained results strongly suggest that ssDNA-FG sensors can be the key to developing a high-performance exhaled breath analyzer for diagnosing halitosis and kidney disorder.",

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note = "Funding Information: Y.J. and H.G.M. contributed equally to this work. This work was partly supported by the KIST Institutional Program (Project No. 2E27270), the Global Top Project funded by the Korean Ministry of Environment (GT-11-F-02-002-1), Nano-Material Technology Development Program (2012M3A7B4049804), the Industrial Technology Innovation Program (10054548) funded by the Ministry of Trade, Industry, & Energy (MI, Korea), and an Institute for Information & Communications Technology Promotion (IITP) grant funded by the Korea government (MSIP) (No. R0126-16-1050, Olfactory Bio Data based Emotion Enhancement Interactive Content Technology Development). Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

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AU - Lim, Chaehyun

AU - Choi, Keunsu

AU - Song, Hyun Seok

AU - Bae, Sukang

AU - Kim, Soo Min

AU - Seo, Minah

AU - Lee, Taikjin

AU - Lee, Seok

AU - Park, Hyung Ho

AU - Jun, Seong Chan

AU - Kang, Chong Yun

AU - Kim, Chulki

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Y1 - 2017/7/12

N2 - Highly sensitive and selective chemiresistive sensors based on graphene functionalized by metals and metal oxides have attracted considerable attention in the fields of environmental monitoring and medical assessment because of their ultrasensitive gas detecting performance and cost-effective fabrication. However, their operation, in terms of detection limit and reliability, is limited in traditional applications because of ambient humidity. Here, the enhanced sensitivity and selectivity of single-stranded DNA-functionalized graphene (ssDNA-FG) sensors to NH3 and H2S vapors at high humidity are demonstrated and their sensing mechanism is suggested. It is found that depositing a layer of ssDNA molecules leads to effective modulation of carrier density in graphene, as a negative-potential gating agent and the formation of an additional ion conduction path for proton hopping in the layer of hydronium ions (H3O+) at high humidity (>80%). Considering that selectively responsive chemical vapors are biomarkers associated with human diseases, the obtained results strongly suggest that ssDNA-FG sensors can be the key to developing a high-performance exhaled breath analyzer for diagnosing halitosis and kidney disorder.

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Humidity-Tolerant Single-Stranded DNA-Functionalized Graphene Probe for Medical Applications of Exhaled Breath Analysis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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