TY - JOUR
T1 - Hydrogen bond removal of pterin derivative whose structure is similar to nucleic acid bases.
AU - Nonogawa, Mitsuru
AU - Arai, Toshiyuki
AU - Endo, Nobuyuki
AU - Pack, Seung Pil
AU - Kodaki, Tsutomu
AU - Makino, Keisuke
PY - 2005
Y1 - 2005
N2 - Pterin, an analog of guanine, is an electron transfer compound in biological systems. Among the analogs, 6-formylpterin (6FP) has been demonstrated to have many marked physiological and pharmacological activities and it is, therefore, worthwhile to elucidate whole mechanism of its activities. Unfortunately, however, 6FP is hardly soluble in water and organic solvents. Like nucleic acid bases, 6FP makes intermolecular hydrogen bonds and forms stacking structure causing such drawback nature. This has made mechanistic studies on 6FP activities extremely difficult. In this study, we carried out derivatization for 6FP and succeeded in increasing water solubility with maintaining its physiological activities.
AB - Pterin, an analog of guanine, is an electron transfer compound in biological systems. Among the analogs, 6-formylpterin (6FP) has been demonstrated to have many marked physiological and pharmacological activities and it is, therefore, worthwhile to elucidate whole mechanism of its activities. Unfortunately, however, 6FP is hardly soluble in water and organic solvents. Like nucleic acid bases, 6FP makes intermolecular hydrogen bonds and forms stacking structure causing such drawback nature. This has made mechanistic studies on 6FP activities extremely difficult. In this study, we carried out derivatization for 6FP and succeeded in increasing water solubility with maintaining its physiological activities.
UR - https://www.scopus.com/pages/publications/39049195233
U2 - 10.1093/nass/49.1.311
DO - 10.1093/nass/49.1.311
M3 - Article
C2 - 17150758
AN - SCOPUS:39049195233
SN - 1746-8272
SP - 311
EP - 312
JO - Nucleic acids symposium series (2004)
JF - Nucleic acids symposium series (2004)
IS - 49
ER -