Hypocholesterolemic effects of the cauliflower culinary-medicinal mushroom, sparassis crispa (Higher basidiomycetes), in diet-induced hypercholesterolemic rats

Ki Bae Hong, Sung Yong Hong, Eun Young Joung, Byung Hee Kim, Song Hwan Bae, Yooheon Park, Hyung Joo Suh

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    The cauliflower culinary-medicinal mushroom, Sparassis crispa, possesses various biological activities that have been widely reported to have therapeutic applications. We examined the effects of S. crispa on serum cholesterol, hepatic enzymes related to cholesterol metabolism, and fecal sterol excretion in rats fed a cholesterolrich diet for 4 weeks. Male Sprague-Dawley rats (8 weeks old) were randomly divided into 5 groups (n = 6 mice per group): normal diet (normal control [NC]), cholesterol-rich diet (cholesterol control [CC]), cholesterol-rich diet plus S. crispa fruiting body (SC), cholesterol-rich diet plus S. crispa extract (SCE), and cholesterol-rich diet plus S. crispa residue (SCR). SCE supplementation significantly enhanced hepatic cholesterol catabolism through the upregulation of cholesterol 7α-hydroxylase (CYP7A1) messenger RNA (mRNA) expression (2.55-fold compared with that in the NC group; P <0.05) and the downregulation of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA expression (0.57-fold compared with that in the NC group; P <0.05). Additionally, the SCE diet resulted in the highest fecal excretion of cholesterol and bile acid in hypercholesterolemic rats. In conclusion, mRNA expression of CYP7A1 and HMG-CoA reductase were significantly modulated by the absorption of SCE samples. Also, SCE samples had a significant effect on fecal bile acid and cholesterol excretion. These results suggest that SCE samples can induce hypocholesterolic effects through cholesterol metabolism and the reduction of circulating cholesterol levels.

    Original languageEnglish
    Pages (from-to)965-975
    Number of pages11
    JournalInternational Journal of Medicinal Mushrooms
    Volume17
    Issue number10
    Publication statusPublished - 2015

    Keywords

    • 3-hydroxy-3-methylglutaryl coenzyme A
    • Cholesterol
    • Cholesterol 7α-hydroxylase
    • Hypercholesterolemia
    • Medicinal mushrooms
    • Sparassis crispa

    ASJC Scopus subject areas

    • Applied Microbiology and Biotechnology
    • Drug Discovery
    • Pharmacology

    Fingerprint

    Dive into the research topics of 'Hypocholesterolemic effects of the cauliflower culinary-medicinal mushroom, sparassis crispa (Higher basidiomycetes), in diet-induced hypercholesterolemic rats'. Together they form a unique fingerprint.

    Cite this