Abstract
Recent tremendous advances in our understanding of the regulation of food intake are expected to contribute to the treatment of obesity in the near future. The hypothalamus is a center for regulation of food intake and NPY/AgRP and POMC neurons are key regulators of food intake in the arcuate nucleus. The level of energy in the body is monitored by energy sensors in the hypothalamus. A variety of signals originating from peripheral organs to sense the status of energy converge on the hypothalamus and diverse neurons in the hypothalamus are involved in determining the output of signal to regulate food intake. Therefore, it is important to understand the signals and energy sensors in the hypothalamus. In this review, we describe the potential role of Akt/PKB signaling as an energy sensor that regulates food intake.
Original language | English |
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Pages (from-to) | 953-966 |
Number of pages | 14 |
Journal | Frontiers in Bioscience - Scholar |
Volume | 4 S |
Issue number | 3 |
DOIs | |
Publication status | Published - 2012 Jan 1 |
Keywords
- AMPK
- Akt/PKB
- Energy balance
- Food intake
- Hypothalamus
- Insulin
- Leptin
- Mtor
- Review
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)