TY - JOUR
T1 - Hypoxemia During Sleep and the Progression of Coronary Artery Calcium
AU - Seo, Min Young
AU - Lee, Seung Hoon
AU - Hong, Sang Duk
AU - Chung, Seung Kyu
AU - Kim, Hyo Yeol
N1 - Funding Information:
This study was supported by National Research Foundation of Korea (NRF) grant funded by Korean government (MEST) (2017R1A2B4006453) and National Research Foundation of Korea (NRF) grant funded by Korean government (Ministry of Education) (NRF-2020R1I1A1A01063604).
Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/1
Y1 - 2021/1
N2 - The aim of this study was to evaluate the associations between objective sleep parameters of obstructive sleep apnea (OSA) and progression of subclinical cardiovascular disease as measured by the coronary artery calcium (CAC) score. We reviewed the medical records of 196 patients who underwent both polysomnography (PSG) and repeated coronary artery computed tomography (CT) for screening purposes. For each participant, the first coronary CT scan was conducted within 12 months of PSG. Follow-up CT was performed voluntarily. The CAC score was log-transformed to obtain normally distributed data. We evaluated potential associations between various sleep parameters by analyzing overnight-attended PSG and CAC score progression over time. ST90 (total sleep time of SaO2 < 90%), CT90 (percentage of time of SaO2 < 90%), and degree of mean oxygen desaturation were significantly correlated with CAC score progression even after adjustment for confounders (age, sex, DM, HTN, hypercholesterolemia, BMI, and smoking status) (estimate = 0.004, p =.010; estimate = 0.009, p <.001; estimate = 0.027, p =.001; respectively). We also performed subgroup analysis and found that the progression of CAC score over time showed higher tendency when CT90 value was 2.73 or more (CT90 ≥ 2.73 group; estimate = 0.336, CT90 < 2.73 group; estimate = 0.194, p <.001 each). ST90, CT90 and mean oxygen desaturation are significant predictors of cardiovascular disease progression. Coronary artery status should be monitored repetitively in patients with hypoxemia during sleep.
AB - The aim of this study was to evaluate the associations between objective sleep parameters of obstructive sleep apnea (OSA) and progression of subclinical cardiovascular disease as measured by the coronary artery calcium (CAC) score. We reviewed the medical records of 196 patients who underwent both polysomnography (PSG) and repeated coronary artery computed tomography (CT) for screening purposes. For each participant, the first coronary CT scan was conducted within 12 months of PSG. Follow-up CT was performed voluntarily. The CAC score was log-transformed to obtain normally distributed data. We evaluated potential associations between various sleep parameters by analyzing overnight-attended PSG and CAC score progression over time. ST90 (total sleep time of SaO2 < 90%), CT90 (percentage of time of SaO2 < 90%), and degree of mean oxygen desaturation were significantly correlated with CAC score progression even after adjustment for confounders (age, sex, DM, HTN, hypercholesterolemia, BMI, and smoking status) (estimate = 0.004, p =.010; estimate = 0.009, p <.001; estimate = 0.027, p =.001; respectively). We also performed subgroup analysis and found that the progression of CAC score over time showed higher tendency when CT90 value was 2.73 or more (CT90 ≥ 2.73 group; estimate = 0.336, CT90 < 2.73 group; estimate = 0.194, p <.001 each). ST90, CT90 and mean oxygen desaturation are significant predictors of cardiovascular disease progression. Coronary artery status should be monitored repetitively in patients with hypoxemia during sleep.
KW - Coronary artery calcium
KW - Hypoxemia during sleep
KW - Obstructive sleep apnea
KW - Subclinical cardiovascular disease
UR - http://www.scopus.com/inward/record.url?scp=85088374781&partnerID=8YFLogxK
U2 - 10.1007/s12012-020-09593-3
DO - 10.1007/s12012-020-09593-3
M3 - Article
AN - SCOPUS:85088374781
SN - 1530-7905
VL - 21
SP - 42
EP - 48
JO - Cardiovascular Toxicology
JF - Cardiovascular Toxicology
IS - 1
ER -
