Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain

Richard C. Li, Seung Kwan Lee, Farzan Pouranfar, Kenneth R. Brittian, Heather B. Clair, Barry W. Row, Yang Wang, David Gozal

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)


Neuroglobin (Ngb) and Cytoglobin (Cygb) are new members of the globin family and display heterotopic expression patterns. To examine the effect of different hypoxia profiles on expression of Ngb and Cygb in rodent brain, rats were exposed to either sustained hypoxia (SH; 10% O2) or intermittent hypoxia (IH; 10% and 21% O2 alternating every 90 s) for 1, 3, 7 and 14 days, and mRNA and protein expression of Ngb and Cygb were assessed in brain cortex. SH increased Ngb mRNA and protein expression throughout the exposure, while IH only elicited slight increases in Ngb expression at day 1. Neither SH nor IH elicited increases in Cygb expression. Thus, hypoxic stimulus presentation is a major determinant of the regulation of hypoxic sensitive genes such as Ngb. Furthermore, disparities between Ngb and Cygb responses to hypoxia further suggest that these two globins may play divergent roles in brain.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalBrain Research
Issue number1
Publication statusPublished - 2006 Jun 22
Externally publishedYes

Bibliographical note

Funding Information:
David Gozal is supported by grants from the National Institutes of Health HL62570, 2P50HL60296, HL69932, and by the Commonwealth of Kentucky Challenge for Excellence Trust Fund.


  • Brain
  • Cytoglobin
  • Hypoxia
  • Neuroglobin

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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