TY - JOUR
T1 - Ideal nozzle position during pressurized intraperitoneal aerosol chemotherapy in an ex vivo model
AU - PIAO, JINLAN
AU - PARK, SOO JIN
AU - LEE, HEESU
AU - KIM, JUNSIK
AU - PARK, SUNWOO
AU - LEE, NARA
AU - KIM, SE IK
AU - LEE, MARIA
AU - SONG, GWONHWA
AU - LEE, JUNG CHAN
AU - KIM, HEE SEUNG
N1 - Funding Information:
This research was supported by Grants from the Seoul National University (No. 800-20170249; 800-20180201) and Seoul National University Hospital (No. 0620173250). Moreover, this study was supported by a grant from the Korean Gynecologic Oncology Group (No. KGOG-SNU-004).
Publisher Copyright:
© 2021 International Institute of Anticancer Research. All rights reserved.
PY - 2021/11
Y1 - 2021/11
N2 - Background/Aim: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is known to show uneven distribution and penetration of agents based on the nozzle position. Thus, this study aimed to investigate the ideal nozzle position for maximizing drug delivery during PIPAC. Materials and Methods: We created 2 cm-, 4 cm- and 8 cmex vivo models according to the distance from the bottom to the nozzle using 21×15×16 cm-sized sealable plastic boxes. After each set of eight normal peritoneal tissues from swine were placed at eight different points (A to H), we performed PIPAC, compared the methylene blue staining areas to investigate the distribution, and estimated the depth of concentrated diffusion (DCD) and the depth of maximal diffusion (DMD) of doxorubicin. Results: In terms of distribution, the 4 cm- and 8 cm-ex vivo models showed more stained faces than the 2 cm-ex vivo model. Regarding the penetration depth, the 4 cm- ex vivo model showed the highest DCD (mean; 244.1 μm, C; 105.1 μm, D; 80.9 μm, E; 250.2 μm, G; 250.2 μm, H) and DMD (mean; 174.8 μm, D; 162.7 μm, E; 511.7 μm, F; 522.2 μm, G; 528.1 μm, H) in the most points corresponding to 62.5%. Conclusion: The ideal nozzle position during PIPAC might be halfway between the nozzle inlet and the bottom in the ex vivo model.
AB - Background/Aim: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is known to show uneven distribution and penetration of agents based on the nozzle position. Thus, this study aimed to investigate the ideal nozzle position for maximizing drug delivery during PIPAC. Materials and Methods: We created 2 cm-, 4 cm- and 8 cmex vivo models according to the distance from the bottom to the nozzle using 21×15×16 cm-sized sealable plastic boxes. After each set of eight normal peritoneal tissues from swine were placed at eight different points (A to H), we performed PIPAC, compared the methylene blue staining areas to investigate the distribution, and estimated the depth of concentrated diffusion (DCD) and the depth of maximal diffusion (DMD) of doxorubicin. Results: In terms of distribution, the 4 cm- and 8 cm-ex vivo models showed more stained faces than the 2 cm-ex vivo model. Regarding the penetration depth, the 4 cm- ex vivo model showed the highest DCD (mean; 244.1 μm, C; 105.1 μm, D; 80.9 μm, E; 250.2 μm, G; 250.2 μm, H) and DMD (mean; 174.8 μm, D; 162.7 μm, E; 511.7 μm, F; 522.2 μm, G; 528.1 μm, H) in the most points corresponding to 62.5%. Conclusion: The ideal nozzle position during PIPAC might be halfway between the nozzle inlet and the bottom in the ex vivo model.
KW - Ex vivo model
KW - Intraperitoneal chemotherapy
KW - Nozzle
KW - Peritoneal metastasis
KW - Pressurized intraperitoneal aerosol chemotherapy
UR - http://www.scopus.com/inward/record.url?scp=85118799625&partnerID=8YFLogxK
U2 - 10.21873/anticanres.15362
DO - 10.21873/anticanres.15362
M3 - Article
C2 - 34732419
AN - SCOPUS:85118799625
SN - 0250-7005
VL - 41
SP - 5489
EP - 5498
JO - Anticancer research
JF - Anticancer research
IS - 11
ER -
